Curriculum Vitae
Todd M. Tuttle, M.D., M.S.

Education
Postdoctoral Training
Staff Positions
Board Certification
License
Honors and Awards
Professional Organizations
Current Administrative and Educational Activities
Current Research Protocols
Published Articles
Book Chapters
Abstracts and Presentations
Invited Presentations

EDUCATION:

1980-1984, Bachelor of Science
Creighton University
Omaha, Nebraska

1984-1988, Doctor of Medicine
Johns Hopkins University School of Medicine
Baltimore, Maryland

2001-2004, Masters in Clinical Research
University of Minnesota School of Public Health
Minneapolis, Minnesota

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POSTDOCTORAL TRAINING:

1988-1990 The Medical College of Virginia
Richmond, Virginia
Surgical Intern and Resident

1990-1992 The Medical College of Virginia
Richmond, Virginia
Surgical Research Fellow; Mentor: Harry D. Bear, M.D., Ph.D.

1992-1994 The Medical College of Virginia
Richmond, Virginia
Surgical Resident

1993-1994 The Medical College of Virginia
Richmond, Virginia
Administrative Chief Resident

1994-1996 M.D. Anderson Cancer Center
Houston, Texas
Surgical Oncology Fellow

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STAFF POSITIONS:

1996-2001 Park Nicollet Clinic
Minneapolis, Minnesota
Surgical Oncology

2001-Present University of Minnesota
Minneapolis, Minnesota
Associate Professor, Surgery

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BOARD CERTIFICATION:

American Board of Surgery
Certificate Number: 39935
February 13, 1995

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LICENSE:

State of Minnesota

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HONORS AND AWARDS:

Alpha Sigma Nu Jesuit Honor Society, Creighton University, 1983
Summa Cum Laude, Creighton University, 1984
Alpha Omega Alpha
Association for Academic Surgery, Resident Research Award, 1991
Society of Surgical Oncology, Armand Hammer Travel Award, 1992
The Humera Surgical Society, David M. Hume Memorial Award, 1992
Virginia Surgical Society, Bigger-Lehman Award, 1st place, 1993
Society of Surgical Oncology, Resident/Fellow Research Award, 1993
"Top Doctors, Surgical Oncology", Minneapolis-St. Paul Magazine
Researcher of the Year, Park Nicollet Clinic, Minneapolis, MN, 2000
Owen Wangensteen Award for Resident Teaching, University of Minnesota, 2001

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PROFESSIONAL ORGANIZATIONS:

American College of Surgeons, FACS
Society of Surgical Oncology
Humera Surgical Society
Minneapolis Surgical Society, Secretary-President
Minnesota Surgical Society
University of Minnesota Cancer Center
Eastern Cooperative Oncology Group
Community Clinical Oncology Program-Metro Minnesota
American Society of Surgical Oncology

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CURRENT ADMINISTRATIVE AND EDUCATIONAL ACTIVITIES:

Medical Director, University of Minnesota Breast Center
Coordinator of Senior Surgical Residents University of Minnesota
Course Director, Sentinel Lymph Node Biopsy for Breast Cancer and Melanoma

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CURRENT RESEARCH PROTOCOLS:

Sunbelt Melanoma Trial
Intraoperative Subareolar Injection of Technetium-99 for Sentinel Lymph Node Identification in Breast Cancer
Hyperthermic Intraoperative Peritoneal Chemotherapy for Gastrointestinal Malignancies

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PUBLISHED ARTICLES:

1. Tuttle T, Williams G, and Marshall F: Evidence for cyclophosphamide-induced transitional cell carcinoma in a renal transplant patient. J Urol 1988; 140:1009.

2. Hoshino T, Tuttle T, Maley W, Smith W, and Williams G: Attempts to induce tolerance with cyclophosphamide after renal transplantation in swine. Transplant Proc 1988; 20:14

3. Hoshino T, Maley W, Stump K, Tuttle T, Burdick J, and Williams G: Evaluation of core-cooling technique for liver and kidney procurement. Transplant Proc 1987: 19:4123.

4. Tuttle T, Inge T, Bethke K, McCrady C, Pettit G, and Bear H: Activation and growth of murine tumor-specific T cells which have in vivo activity with bryostatin 1. Cancer Res 1992; 52:548.

5. Tuttle T, Bethke K, Inge T, McCrady C, Pettit G, and Bear H: Bryostatin 1-activated T cells can traffic and mediate tumor regression. J Surg Res 1992; 52:543.

6. Tuttle T, Inge T, McCrady C, Bethke K, and Bear H: Phorbol dibutyrate plus calcium ionophore can activate CD8+ murine T cells from tumor-draining lymph nodes which are capable of mediating tumor regression. J Immunother 1992; 12:32.

7. Tuttle T, Inge T, Wirt P, Frank J, McCrady C, and Bear H: Bryostatin 1 activates T cells which have anti-tumor activity. J Immunother 1992, 12:75.

8. Tuttle T, Inge T, and Bear H: Adoptive transfer of bryostatin 1-activated T cells provides long-term protection against tumor metastases. Surg Onc 1992; 1:299.

9. Tuttle T, McCrady C, Inge T, and Bear H: Interferon-gamma plays a key role in T cell induced tumor regression. Cancer Res 1993; 53:833.

10. Lind D, Tuttle T, Bethke K, Frank J, Fleming M, McCrady C, and Bear H: Expansion and tumor-specific cytokine secretion of bryostatin 1-activated T cells from cryopreserved axillary lymph nodes of breast cancer patients. Surg Oncol 1993; 2:273.

11. Tuttle T, Fleming M, Hogg P, Inge T, and Bear H: Low-dose cyclophosphamide overcomes metastasis-induced immunosuppression. Ann Surg Onc 1994; 1:53.

12. Sternbergh W, Tuttle T, Makhoul R, Bear H, Sobel M, and Fowler A: Post-ischemic extremities exhibit immediate release of tumor necrosis factor. J Vasc Surg 1994; 20:474.

13. Baldwin N, Rice C, Tuttle T, Bear H, Hirsch J, and Merchant R: In vitro expansion of tumor-draining lymph node cells using compounds which activate intracellular signal transduction. J Neuro Oncology, 1997; 32:19-28.

14. Tuttle T, Curley S, and Roh M: Repeat hepatic resection is effective treatment of recurrent colorectal liver metastases. Ann Surg Oncology, 4:125-130, 1997.

15. Tuttle T: Oncogene products represent potential targets of tumor vaccines. Cellular Immunol Immunother, 43: 135-141, 1996.

16. Tuttle T and Ioannides C: Macrophage infiltrate and prognosis in c-erb B-2 overexpressing breast carcinomas (edit). Breast Diseases: A Year Book Quarterly, 1997, 7:370-371.

17. McMasters K, Tuttle T, Leach S, Martin R, Evans D, and Curley S: Neoadjuvant chemoradiation for cholangiocarcinoma. American J Surg, 174:605-8, 1997

18. Tuttle T, Anderson B, Thompson W, et al: Proliferative and cytokine responses to Class II HER-2/neu-associated peptides in breast cancer patients. Clinical Cancer Research, 4:2015-2024, 1998.

19. McMasters K, Wong S, Tuttle T, et al: Preoperative lymphoscintigraphy for breast cancer does not improve the ability to accurately identify axillary sentinel lymph nodes. Ann Surg 231:724-31, 2000.

20. Martin R, Edwards M, Wong S, Tuttle T, et al: Practical guidelines for optimal gamma probe detection of sentinel lymph node in breast cancer: results of a mult-institutional study. Surgery 128:139-44, 2000

21. McMasters K, Tuttle T, Carlson D, Brown C, et a: Sentinel lymph node biopsy for breast cancer: a suitable alternative to routine axillary dissection in multi-institutional practice when optimal technique is used. J Clin Oncol 18:2560-6, 2000.

22. Wong, S, Edwards M, Chao C, Tuttle T, Noyes R, Woo C, Cerrito P, and McMasters K. Predicting the status of the non-sentinel axillary nodes: a multicenter study. Arch Surg 136:563-568, 2001.

23. Swenson K, Sladek M, Lally R, and Tuttle T. Educating patients on sentinel lymph node dissection for breast cancer. Cancer Practice 9: 92-96, 2001.

24. McMasters K, Wong S, Martin R, Chao C, Tuttle T, Noyes R, Carlson D, Laidley A, McGlothin T, Ley P, Brown C, Glaser R, Pennington R, Turk P, Simpson D, Cerrito P, Edwards M. Dermal injection of radioactive colloid is superior to peritumoral injection for breast cancer sentinel lymph node biopsy: results of a multi-institutional study. Ann Surg 233:676-87, 2001.

25. Tuttle T, Colbert M, Christensen R, Ose K, Jones T, Wetherille R, Friedman J, Swensen K, and McMasters K. Subareolar injection of technetium-99 facilitates sentinel lymph node identification. Submitted to Ann Surg Onc, 2001.

26. Wong S, Edwards M, Chao C, Tuttle T, Noyes R, Carlson D, Cerrito P, and McMasters K. Sentinel lymph node biopsy for breast cancer: impact of the number of sentinel nodes on the false negative rate. J Am Coll Surg 2001;192:684-691.

27. Wong S, Chao C, Edwards M, Tuttle T, Noyes R, Carlson D, Laidley A, McGothin T, Ley P, Brown M, Glaser R, Pennington R, Turk P, Simpson D, and McMasters K. Accuracy of sentinely lymph node biopsy for patients with T2 and T3 breast cancers. The American Surgeon 2001; 67:522-528.

28. McMasters K, Wong S, Chao C, Woo C, Tuttle T, Noyes R, Carlson D, Laidley A, McGlothin T, Lew P, Brown C, Glaser R, Pennington R, Turk P, Simpson D, and Edwards M. Defining the optimal surgeon experience for breast caner sentinel lymph node biopsy: a model for implementation of new surgical techniques. Submitted, 2001

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PUBLICATIONS: BOOK CHAPTERS:

1. Tuttle T. Esophageal Cancer. In Lee K and Dyke C: Surgical Attending Rounds, Philadelphia, Lea and Febiger, 1992, pp 47-56.

2. Tuttle T. Anorectal Disease. In Lee K and Dyke C: Surgical Attending Rounds, Philadelphia, Lea and Febiger, 1992, pp171-178.

3. Bear H and Tuttle T. Adoptive Immunotherapy with Pharmacologically Activated T Lymphocytes. In Chang A and Shu S: Immunotherapy of Cancer with Sensitized T Lymphocytes, R.G. Landes Company, 1994, pp35-51.

4. Saltzman D and Tuttle T. Anorectal Disease. In Lee K and Dyke C: Surgical Attending Rounds (2nd edition), Philadelphia, Lea and Febiger, 1997.

5. Gorden D and Tuttle T. Cancer of the Colon and Rectum. In Lee K and Dyke C: Surgical Attending Rounds (2nd edition), Philadelphia, Lea and Febiger, 1997.

6. Tuttle T. Hepatectomy for Noncolorectal Liver Metastases. In Curley SA: Liver Cancer, Springer-Verlag, New York, 1998.

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ABSTRACTS AND PRESENTATIONS:

1. Hoshino T, Tuttle T, Maley W, Smith W, and Williams G: Attempts to induce tolerance with cyclophosphamide after renal transplantation in swine. Int Organ Transplantation Forum, 1987.

2. Hoshino T, Maley W, Stump K, Tuttle T, Burdick J, and Williams G: Evaluation of core-cooling technique for liver and kidney procurement. Eur Soc Organ Transplantation, 1987.

3. Tuttle T, and Bear H: Generation of cytotoxic T cells with phorbol ester and calcium ionophore. FASEB, 1991.

4. Tuttle T, and Bear H: Therapeutic efficacy of lymphocytes stimulated with phorbol dibutyrate and ionomycin. Eleventh Annual Cancer Forum, American Cancer Society, Virginia Division, 1991.

5. Tuttle T, McCrady C, Inge T, and Bear H: Bryostatin generates T cells with anti-tumor activity. Surgical Forum, 1991.

6. Tuttle T, Bethke K, Inge T, McCrady C, Pettit G, and Bear H: Bryostatin 1-activated T cells can traffic and mediate tumor regression. Association for Academic Surgery, 1991.

7. Tuttle T, Inge T, Lind D, and Bear H: Adoptive transfer of bryostatin 1-activated T cells provides long-term protection against tumor metastases. Society of Surgical Oncology, 1992.

8. Tuttle T, Inge T, Lind D, and Bear H: Tumor-draining lymph node cells activated with bryostatin 1 induce long-term tumor immunity. Twelve Annual Cancer Forum, American Cancer Society, Virginia Division, 1992.

9. Tuttle T, and Bear H: T cell activation with bryostatin 1 and a calcium ionophore. Virginia Society of Hematology and Oncology, 1992.

10. Tuttle T, Lind D, and Bear H: Interferon-gamma plays a key role in T cell-induced tumor regression. Association for Academic Surgery, 1992.

11. Tuttle T, Fleming M, Hogg P, Inge T, and Bear H: Low-dose cyclophosphamide overcomes metastasis-induced immunosuppression. Society of Surgical Oncology, 1993.

12. Baldwin N, Rice C, Tuttle T, Bear H, and Merchant R: In vitro expansion of lymphocytes sensitized to glioma using compounds which enhance intracellular transduction. American Association of Neurological Surgeons, 1992.

13. Lind D, Tuttle T, Bethke K, Frank J, McCrady C, and Bear H: Expansion of tumor-reactive, cytokine-secreting T cells from frozen axillary lymph nodes of breast cancer patients using bryostatin 1 activation. San Antonio Breast Conference, 1992.

14. Tuttle T, and Salzberg A: Repair of H-type tracheoesophageal fistula (Motion Picture), American College of Surgeons Annual Meeting, 1993.

15. Tuttle T, Curley S, and Roh M: Repeat hepatic resection is effective treatment of recurrent colorectal liver metastases. Society of Surgical Oncology, 1996.

16. Tuttle T, Fleming R, Tyler D, Staley C, Cusak J, Curley S, and Roh M: Survival following hepatic resection of non-colorectal liver metastases. Society of Surgery of the Alimentary Tract, 1996.

17. Melichar B, Hudson J, Honda T, Tuttle T, Murray J, Wharton J, and Ioannides C: Characterization of antigen recognition in tumor infiltrating lymphocytes in breast cancer. FASEB, 1996.

18. Tuttle T, Curley S, and Roh M: Determinants of survival following hepatic resection of non-colorectal liver metastases. Minnesota Surgical Society, 1996.

19. Lee J, Lu M, Thompson W, Tuttle T, McMasters K, Frasier M, and Evans D: Association of HLA-DQB1*0301 with lymph node metastases and survival in resectable adenocarcinoma of the pancreas. Society of Surgery of the Alimentary Tract, 1996

20. Tuttle T, Spitz F, Hunt K, Pisters P, Skibber J, Pollock R, and Feig B. Primary colorectal sarcomas: a guide to surgical management. Society of Surgical Oncology, 1997.

21. McMasters K, Tuttle T, Leach S, Martin R, Evans D, and Curley S: Neoadjuvant chemoradiation for cholangiocarcinoma. Southwest Surgical Society, 1997.

22. Tuttle T, Gamble W, Swenson K, Simpson R, and Manoles E. Sentinel lymph node biopsy can detect occult nodal metastases from breast cancer, Minnesota Surgical Society, 1999.

23. Swenson K, Nissen M, and Tuttle T. Short-term complications of sentinel lymph node biopsy for breast cancer. Seeking Excellence in Breast Cancer Care, The Johns Hopkins Breast Center, 1999.

24. Swenson K, Nissen M, and Tuttle T. Lymphatic mapping and sentinel node biopsy for breast cancer. Oncology Nursing Society, 1999.

25. McMasters K, Wong S, Tuttle T, Carlson D, Brown C, Noyes R, Glaser R, Vennekotter D, Turk P, Tate P, Sardi A, and Edwards M. Sentinel lymph node biopsy for breast cancer: obtaining a preoperative lymphoscintigram does not improve SLN identification or false-negative rates. Southern Surgical Association, 1999.

26. McMasters K, Martin R, Wong S, Tuttle T, Noyes R, and Edwards M. Optimal gamma probe detection of sentinel lymph nodes in breast cancer: results of a nationwide multi-institutional study. Society of University Surgeons, 2000.

27. Tuttle T, and Swenson K. Subareolar injection may facilitate sentinel lymph node identification for breast cancer. Minnesota Surgical Society, 2000.

28. Ioannides C, Tuttle T, Peoples, G, et al. Epitope-specific T-cell immunity to breast cancer. The Department of Defense Breast Cancer Research Program Meeting, 2000.

29. Wong S, Edward M, Tuttle T, Noyes R, Carlson D, Brown C, Glaser R, Turk P, Laidley A, Sardi A, Simpson D, Cerrito P, McMasters K. Sentinel lymph node biopsy for breast cancer: impact of the number of sentinel nodes on the false negative rate. American College of Surgeons Clinical Congress, 2000.

30. Swenson K, Nissen M, Ceronsky C, and Tuttle T. Comparison of side effects between sentinel lymph node and axillary lymph node dissection for breast cancer. Oncology Nursing Forum, 2001.

31. McMasters, K, Carlson D, Brown M, Glaser R, Turk P, Laidley A, Tuttle T, Noyes R, McGl;othin T, Ley P, Pennington R. Defining the optimal surgeon experience for breast cancer sentinel lymph node biopsy: A model for implementation of new surgical techniques. American Surgical Association, 2001.

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INVITED PRESENTATIONS:

1. Tuttle T. Generation and expansion of cytotoxic T lymphocytes using alternate pathways of activation. The Eastern Surgical Society, 1991.

2. Tuttle T. Bryostatin 1-activated T cells can traffic and mediate tumor regression. The Humera Surgical Society, 1992.

3. Tuttle T. Interferon-gamma plays a key role in T cell-induced tumor regression. The Virginia Surgical Society, 1993.

4. Tuttle T. Lymphadenectomy for Persistent Medullary Thyroid Cancer. The Walter Lawrence, JR, The Medical College of Virginia, 1995.

5. Tuttle T. Surgical Treatment of Cutaneous Melanoma. Department of Dermatology, University of Minnesota Grand Rounds, 1997.

6. Tuttle T, Recent Advances in Melanoma. Grand Rounds, HealthSystem Minnesota, 1997.

7. Tuttle T, Lymphatic Mapping for Melanoma and Breast Cancer, Tumor Conference, Duluth Minnesota, 1997.

8. Tuttle T. Innovative surgical procedures for the treatment of cancer. Metro Minnesota Oncology Nurses' Society, 1998.

9. Tuttle T. Cryosurgical ablation of hepatic neoplasms. Minneapolis Surgical Society, 1998.

10. Tuttle T. Innovative surgical procedures for the treatment of cancer. American Cancer Society, College of St. Catherine, St. Paul, Minnesota, 1998.

11. Tuttle T. Breast Lymphatic Mapping: Gimmick or Standard of Care? Department of Surgery Grand Rounds, University of Minnesota, 1998.

12. Tuttle T. Lymphatic Mapping for Melanoma and Breast Cancer, Tumor Conference, Rice Memorial Hospital, Wilmar, Minnesota, 1998.

13. Tuttle T, Lymphatic Mapping for Melanoma and Breast Cancer, Tumor Conference, Mankato, Minnesota, 1998.

14. Tuttle T, Lymphatic Mapping for Melanoma and Breast Cancer, Tumor Conference, Rapid City, Minnesota, 1998.

15. Tuttle T, Cryosurgical Ablation of Liver Tumors, CryoMedical Sciences Course, 1998.

16. Tuttle T. Pancreatic Cancer Diagnosis and Management, Grand Rounds, HealthSystem Minnesota, 1998

17. Tuttle T. Lymph Node Mapping. Breast Diagnosis Update, Sarasota Florida, 1999

18. Tuttle T. Sentinel Lymph Node Biopsy For Colon Cancer, University of Louisville Sentinel Lymph Node Biopsy Course, 1999.

19. Tuttle T. Sentinel Lymph Node Biopsy For Breast Cancer, Grand Rounds, St. Vincent's Hospital, Green Bay, Wisconsin, 1999.

20. Tuttle T. Sentinel Lymph Node Biopsy For Breast Cancer, Grand Rounds, St. Mary's Hospital, Milwaukee, Wisconsin, 1999.

21. Tuttle T. Sentinel Lymph Node Biopsy For Breast Cancer, Grand Rounds, Ridges Hospital, Burnsville, Minnesota, 1999.

22. Tuttle T. Update on Sentinel Lymph Node Biopsy for Melanoma, National Melanoma Advisory Board, Deer Valley Utah, 2000.

23. Tuttle T. Overview of Lymphatic Mapping and Sentinel Lymph Node Biopsy. Lakeview Symposium, St. Joseph, Michigan, 2000.

24. Tuttle T. Molecular staging of melanoma. University of Minnesota Department of Surgery Grand Rounds, 2000.

25. Tuttle T. Melanoma: Therapeutic Advances in High-Risk and Metastatic Disease. University of South Dakota School of Medicine. 2000.

26. Tuttle T. Sentinel lymph node biopsy for breast cancer. Ridgeview Medical Center Grand Rounds, Waconia, MN 2000.

27. Tuttle T. Sentinel lymph node biopsy for breast cancer. Faith Regional Medical Center, Norfolk, NE, 2001.

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