Curriculum Vitae
James D. St. Louis, M.D.

Education
Honors and Awards
Licenses and Certification
Professional Memberships
Academic Appointments
Hospital Appointments
Research Grants
Research Activity
Committee Memberships and Appointed Positions
Publications
Other Publications
Abstracts
Presentations

EDUCATION:

B.A., Merrimack College, North Andover, MA
Graduated 1986, Magna Cum Laude  

M.D., Georgetown University School of Medicine
Graduated 1992, Kober Scholar (1 of 210 Class Ranking)

Postgraduate Training

1992-1993, Intern in Surgery
Duke University Medical Center

1994-1996, NIH Surgical Research Scholar
Duke University Medical Center

1993-1994, Junior Assistant Resident
Duke University Medical Center

1996-1998, Senior Assistant Resident
Duke University Medical Center

1998-1999, Chief Resident, General Surgery
Duke University Medical Center

1999- 2001, Cardiothoracic Surgery
Duke University Medical Center

2001-2002, Fellow
Pediatric and Neonatal Cardiac Surgery
Children’s Mercy Hospital, Kansas City, Missouri

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HONORS AND AWARDS:

Junior Alpha Omega Alpha, Georgetown, School of Med, 1991
Kober Medal (Class rank 1 of 210) Georgetown, School of Med, 1992
Cahill Award, Outstanding Surgical Student, Georgetown, 1992
Upjohn Achievement Award, Research, Georgetown, 1992
Egypt Society of Cardiology, Medal of Honor, 1996

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LICENSES AND CERTIFICATION:

Georgia, 2003
North Carolina, 1994
Missouri, 2001
Rhode Island, 2002
American Board of Surgery (45824), 2000
American Board of Thoracic Surgery (6732), 2002

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PROFESSIONAL MEMBERSHIPS:

Sigma Xi Scientific Research Society
Alpha Omega Alpha
American College of Surgeons, Candidate
American Medical Association
Association for Academic Surgery
Southern Thoracic Surgical Association
Society of Thoracic Surgeons
American College of Cardiology
American Heart Association
Georgia Medical Association

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ACADEMIC APPOINTMENTS:

2002-2003, Assistant Professor of Surgery
Brown University Medical School, Providence, RI

2003-present, Assistant Professor of Surgery
Medical College of Georgia

2007-present,  Associate Professor of Cardiothoracic and Vascular Surgery Associate Professor of Pediatrics
Medical College of Georgia

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HOSPITAL APPOINTMENTS:

2003-present, Medical College of Georgia
Active Staff

2003-present, Children’s Medical Center
Medical College of Georgia - Active Staff

2002-2003, Rhode Island Hospital, Providence, RI
Inactive, Department of Surgery

2002-2003, Hasbro Children’s Hospital
Inactive Staff, Department of Surgery

2002-2003, Vice-Chief of the Pediatric Cardiac Surgery Program
Hasbro Children’s Hospital

2002-3003, Director of the Failing Heart Program
Hasbro Children’s Hospital

2002-2003, The Miriam Hospital
Inactive Staff, Department of Surgery

2002-2003, Women and Infants Hospital
Inactive Staff, Department of Surgery

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RESEARCH GRANTS:

2003, The Rhode Island Medical Foundation
Role: Principle Investigator
"Characterization of the Inflammatory Response to Cardiopulmonary Bypass in the Neonate: Effects on Cytokine and Adhesion Molecule Expression"

2004-2006, Victor H Moore Research Grant
"Expression of CD 163 in Hypoxic Neonatal Swine undergoing Cardiopulmonary Bypass"

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RESEARCH ACTIVITY:

1) Monocyte/macrophage function in chronically hypoxic rat lungs

Monocytes have been shown to have a roll in pulmonary artery adventitial thickening in chronically hypoxic animals. We are investigating the signaling mechanism involved trafficking monocytes to these specific sites.

2) Characterization of CD163 expression in children undergoing correction of congenital defects of the heart

Children undergoing cardiopulmonary bypass may have an severe inflammatory response. This response is multifold, but overwhelming hemolysis may have a significant role. We are investigating a macrophage surface receptor, CD163, for it roll in this response.

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COMMITTEE MEMBERSHIPS AND APPOINTED POSITIONS:

2004-2007, MCG - Transfusion Subcommittee, Joint Committee of CMC Medical Staff and MCG-MC Medical Staff

2004-2005, MCG - Pharmacy and Therapeutics Subcommittee, Joint Committee of CMC Medical Staff and MCG-MC Medical Staff

2004-2007, Imaging Oversight Committee

2004-2007, Pediatric Cardiac Planning Committee

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PUBLICATIONS:

1. Cherington V, Brown M, Pouch E, St. Louis J, Spiegelman BM, Roberts TM: “Separation of Simian Virus 40 Large -T antigen Transforming and Origin- Binding Function from the Ability to Block Differentiation” Mol Cell Biol 8(3): 1380 - 4, Mar 1988.

2. St. Louis J, Corcoran PC, Rajan S, Conte J, Wolfinbarger L, Hu J, Wang YN, Hilbert S, Analouei A, Hopkins RA: “Characterization of Effects of Warm Ischemia Following Harvesting of Allograft Cardiac Valves.”  European Journal of Cardiothoracic Surgery (1991) 5: 485-465.

3. Hopkins, RA, St Louis J, Corcoran PC: “Ross' first homograft replacement of the aortic valve.  Ann Thorac Surg, 1991.  52(5): p.1190-3.

4. Corcoran P, Wang Y, Katz N, St. Louis J, Foegh M, Rajan S, Analouei A, Wallace R: “Platelet activating factor antagonist enhances lung preservation”.  J Surg Res, 1992. 52(6): p. 615-20.

5. Crescenzo D, Hilbert S, Barrick M, Corcoran P, St. Louis J, Messier R, Ferrans V, Wallace R, Hopkins R:  “Donor heart valves: electron microscopic and morphometric assessment of cellular injury induced by warm ischemia.  J Thorac Cardiovasc Surg, 1992.  103(2): p. 253-7.

6. Corcoran P, Tse S, Katz N, Wang Y, St. Louis J, Foegh M, Analouei A, Wallace R: “ Reduction of conjugated dienes in lung transplantation: effect of BN 52021.  Ann Thorac Surg, 1993.  56(6): p. 1279-83.

7. Abdel-aleem S, Sayed-Ahmed M, Nada M, Hendrickson S, St. Louis J, Lowe J: “Stimulation of Non-Oxidative Glucose Utilization by L-Carnitine in Isolated Myocytes” J Mol Cell Cardiol, 27, 2465-72 1995.

8. Plunkett MD, Hendry PJ, Anstadt MP, Camporesi EM, Amato MT, St. Louis JD, Lowe JE: “Chronic Hypoxia Induces Adaptive Metabolic Changes in Neonatal Myocardium” J Thorac Cardiovascular Surg, 112(1): 8-13, 1996.

9. Anstadt MP, Perez-Tamayo RA, Davis MG, Hagen PO, St. Louis JS, Hendrickson SC, Abdel-aleem S, Reimer KA, Anstadt GL, Lowe JE: “Experiential Aortocoronary Saphenous Vein Graft Function After Mechanical Cardiac Massage” ASAIO, 42(4): 295-300, 1996.

10. Abdel-aleem S, Sayed-Ahmed M, Nada M, Hendrickson S, St. Louis J, Walthhall HP, Lowe JE: Regulation of fatty acid oxidation by acetyl-CoA generated from glucose utilization in isolated myocytes.  J Mol Cell Cardiol  28 (5) 825-33, 1996.

11. Hendrickson S, St. Louis J, Lowe JE, Abdel-aleem S: Free Fatty acid metabolism during myocardial ischemia and reperfusion.  Mol Cell Biochem 166: 85-94, 1997.

12. Hughes C, Lowe J, Kypson A, St. Louis J, Pippen A, Petters K, Coleman E, DeGrado T, Donavan C, Annex B, Landolfo K: Neovascularization After Transmyocardial Laser Revascularization in a Model of Chronic Ischemia; Ann Thorac Surg  66: 2029- 36, 1998.

13. Abdel-Aleem, St. Louis J, Lowe J: Regulation of carbohydrate and fatty acid utilization by L-carnitine during cardiac development and hypoxia: Mol Cell Biochem 180: (1-2) 95-103, 1998.

14. Abdel-Aleem S, St. Louis J, Lowe J: Metabolic changes in the normal and hypoxic myocardium: Ann NY Acad Sci 874: 254-61, 1999.

15. St. Louis J, Leight G, Tyler D: Follicular Neoplasms: The Role for Observation, Fine Needle Aspiration Biopsy, Thyroid Suppression and Surgery.  Semin. Surg. Oncol 16: 5-11, 1999.

16. Hughes G, Kypson A, St. Louis J, Annex B, Coleman R, Degrado T, Donovan C, Lowe J, Landolfi K: “Improved perfusion and contractile reserve following transmyocardial laser revascularization in a  model of hibernating myocardium” Annals of Thoracic Surg, 67 (6): 1714-20, 1999.

17. Hughes GC, Kypson AP, St. Louis JD, Annex BH, Coleman RE, Degrado TR, Donavan CL, Lowe JE, Landolfo KP: Induction of angiogenesis after TMR: a comparison of holmium: YAG, CO2, and excimer.  Ann Thorac Surg 70 (2): 504-9, 2000.

18. St. Louis JD, Hughes C, Kypson A, Degrado TR, Donavan CL, Coleman RE, Yin B, Abdel-Aleem S, Steenbergen C, Landolfo KP, Lowe JE: An experimental model of chronic myocardial hibernation.  Ann Thorac Surg 69 (5): 1351-7, 2000.

19. Hughes GC, Kypson AP, St. Louis JD, Annex BH, Coleman RE, Degrado TR, Donovan CL, Lowe JE,  Landolfo KP: Induction of angiogenesis after TMR: a comparison of holmium, YAG, CO2 and excimer. Ann Thorac Surg 70 (2) 504-509, 2000.

20. Forbess JM, Sha AS, St. Louis JD, Jaggers JJ, Ungerleider RM: “Cryopreserved homografts in the  pulmonary position: determinants of durability” Ann  Thorac Surg, 71 (1): 54-59, 2001.

21. Patel VS, St. Louis JD, Oduntan O, Landolfo KP. “Intrathoracic Peripheral Nerve Sheath Tumors in  Patients with Neurofibromatosis Type 1 (Von Reckinghausen’s Disease)”   J Thorac Cardiovasc Surg.  2006 Mar; 131(3):736-7.

22. St. Louis J: Stage I Palliation for Interrupted “Right” Aortic Arch Associated with Mitral Atresia. Ann Thorac Surg (Accepted in Press) 2006.

23. St. Louis J:  Pentalogy of Cantrell Associated with Hypoplastic Left Heart Syndrome and Herniation of  the Ventricular Mass into the Abdominal Cavity. Interactive Cardiovascular and Thoracic Surgery,  2006 June, 5(3): 200-202.

24. St. Louis J, Bannan M, Lutin W, Wiles: Surgical Strategies and Outcomes in Patients with Shones Complex: A Retrospective Review. Ann Thorac Surg 84: 1357-63, 2007.

25. St. Louis J, Wheeler, Derek, Wiles H: Elective use of the left ventricular assist after delayed arterial switch operation for D-transposition of the great vessels with intact ventricular septum. J Thorac Cardiovasc Surg. 2007 July, 134: 252-253. 

26. Wheeler DS, St. Louis JD: Pentalogy of Cantrell associated with Hypoplastic Left Heart Syndrome. Pediatr Cardiol. 2007 Aug 28(4): 311-313.

27. Qian Zhang, Sonali Gupta, Pulkit Malik, Davin Jagnandan, Mario B. Marrero,
James. D. St Louis, R.Daniel Rudic, David W. Stepp, David J.R. Fulton: NADPH Oxidase 5 is Expresed in Human Blood Vessels and Activates Endothelial Nitric Oxide Synthase. (Submitted)

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OTHER PUBLICATIONS:

1. St. Louis J, Reed LR:  “Laparoscopic Evaluation in Abdominal Trauma”.  Atlas of Laparoscopic Surgery, Theodore N. Pappas (ed) Current Medicine, 1996, pp. 20.2-20.20.9

2. St. Louis J, Sebastian M, Reed R, Vaslef S: “Laparoscopic Evaluation in Abdominal Trauma”.  Atlas of Laparoscopic Surgery  2nd ed, Pappas, Cheken, Eubanks (ed) Current Medicine, 2000, pp. 22-29.

3. St. Louis J: “Shock”: The Handbook of Surgical Intensive Care: Practices of the Surgical Residents at Duke University Medical Center, 5th edition, Clary and Milano (eds) Mosby 2000, pp. 9-17

4. Lowe LE, Sabiston DC, St. Louis JD: “Congenital Malformation of the Coronary Circulation”.  Textbook of Surgery.  The Biological Basis of Modern Surgical Practice, 15th Edition, David C Sabiston (ed) W.B. Saunders Co., 1996, pp. 2001-2011.

5. St. Louis J, Hopkins R. “The Biological Valve Spectrum and a Rational for Prosthetic Valve Choice”   2nd ed. Spring-Verlag, New York, 2005, pp 602-612.

6. St. Louis J, McCann R: “Lymphedema”: Sabistons Textbook of Surgery.  The Biological Basis of Modern Surgical Practice, 16th Edition, Townsand (ed) W.B. Saunders Co., 2001, pp 1446-1452

7. St. Louis J, Jaggers J. “Left Ventricular outflow tract obstruction”: Critical Heart Disease in Infants and Children,  2nd Edition, Nichols (ed) Mosby, 2006, pp 609 -625.

8. St. Louis J. “Truncus Arteriosus”: Critical Heart Disease in the Infant and Children, 2nd Edition, Nichols (ed) Mosby, 2006, pp 689-699

9. Wheeler D, St. Louis J. “Congenital Heart Disease: Left to Right Shunt Lesions”: Pediatric Critical Care Medicine: Basic Science and Clinical Evidence, 1st Edition, Wheeler, Wong and Shanley, Springer-Verlag, 2007 (in press)

10.  St.Louis J    Nomenclature and Classification of Congenital Anomalies of the Heart” : Pediatric Critical Care Medicine: Basic Science and Clinical Evidance, 1st Edition, Wheeler, Wong and Shanley, Springer-Verlag, 2007  (in press)

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ABSTRACTS:

1. St. Louis J, Corcoran P, Rajan S, Conte J, Wahlstrom T, Wolfinbarger L, Hu J, Wang Y, Analouei A, Hopkins R: “Biochemical Characterization of Warm Ischemic Injury to Valve Leaflet Fibroblasts in a Porcine Model using Proton (1H) Magnetic Resonance Spectroscopy.”  Journal of the American College of Cardiology: Abstracts 15: 2, 1990.

2. Corcoran P, Wang Y, St. Louis J, Foegh M, Ramwell P, Rajan S, Analouei A, Wallace R, Katz N: Effects of Lung Preservation Solution on Differential Lung Function and Pulmonary Hemodynamics in an Acute Canine Model.”  Surgical Forum Volume XLI, The American College of Surgeons, San Francisco, California, October 7-12, 1990.

3. Corcoran PC, Rajan SS, St. Louis JD, Wang YN, Analouei AR, Wallace RB, Hopkins RA: “ Lorentzian Analysis of Phosphorus Magnetic Resonance Spectroscopy (31 MRS) of Fresh and Cryopreserved Porcine Cardiac Semilunar Valve Leaflet Fibroblasts: A Marker of Metabolic Reserve.”  Cryo ‘90, The Society of Cryobiology, SUNY, Binghamton, New York, June 17 - 23, 1990.

4. Corcoran P, Rajan S, St. Louis J, Wang YN Wallace R, Hopkins R: “Proton (1H) and Phosphorus (31P) Magnetic Resonance Spectroscopy of Fresh and Cryopreserved Porcine Semilunar Cardiac Valves: Characterization of Warm Ischemic Injury and Assessment of Cellular Viability.” 9th Annual Meeting, The Society of Magnetic Resonance in Medicine, New York, August 18 - 24, 1990.

5. Conte JV, Katz NM, Foegh ML, Ramwell PW, St. Louis J, Wahlstrom T, Wallace RB: “Reduced Reperfusion Injury by Iron Chelation in Canine Single Lung Transplantation.”  Program of American Association for Thoracic Surgery 1990, Annual Meeting, May 8-12, 1990, Toronto, Canada, p. 54.

6. Plunkett MD, Hendry PJ, Anstadt MP, St. Louis J, Lowe JE: Chronic Hypoxia Induces Pulmonary Hypertension and Right Ventricular Hypertrophy in the Neonate. Society of Thoracic Surgeons 31:22, 1995

7. Abdel-aleem S, Nada M, Sayed-Ahmed M, St. Louis J, Hendrickson S, Whalthall H Lowe JE: The Specificity of L-Carnitine to Acetyl-Co A Generated from Carbohydrate Metabolism in Isolated Cardiac Cells.  J Mol and Cell Cardiol 27: 34, 1995

8. Abdel-aleem S, Sayed-Ahmed M, Hendrickson S, St. Louis JD, Lowe JE: Regulation of Glucose Utilization by L-Carnitine in Cardiac Myocytes.  JACC 44: 917-98, 77A, 1995.

9. Abdel-aleem S, Sayed-Ahmed M, Hendrickson S, St. Louis JD, Lowe JE: Reversal of the Alteration of Fatty Acid Oxidation in Adriamycin-Induced Cardiomyopathy by L-Carnitine. FASEB 9 (3): A156 (909), 1995.

10. St. Louis J, Lowe J, Hendrickson S, Anstadt M, Perez-Tamayo R, Elberry J, Landolfo K: The Duke Clinical Experience with Non-Blood Contacting Biventricular Cardiac Support.  The 3rd Congress of the International Society for Rotaty Blood Pumps.  ASIAO, Abstract 72, 1995

11. St. Louis J, Hendrickson S, Abdel-aleem S, Lowe J: Duke Clinical Experience with Transmyocardial Laser Revascularization.  22nd Meeting of the Egyptian Society of Cardiology.  Invited Abstract.  March 1st, Luxor, Egypt, 1996.

12. St. Louis J, Hendrickson S, Plunkett M, Darwod D, Zarouk W, Lowe J, Abdel-Aleem S: Cellular Metabolism During Myocyte Maturation: Role of L-Carnitine.  J Mol and Cell Card, 1996.

13. St. Louis J, Hendrickson S, Plunkett M, Abdel-aleem S, Reed R, Lowe J: Differential Expression of the Constitutive Form of the Nitric Oxide Synthase (cNOS) in the Lung.  J Mol and Cell Card, 1996.

14. Lowe J, St. Louis J, Hendrickson S, Landolfo K: A New Experimental Model of Hibernating Myocardium: Results of TMR Perfusion.  AAMI, June 1996.

15. Hendrickson S, St. Louis J, Dawod D, Abdel-aleem S, Lowe J: Inhibition of Free Fatty Acid Oxidation with 2-Bromopalmitate Improved Cardiac Function Following Global Ischemia Independent of Long Chain Acylcarnitine Levels: Surgical Forum, Volume XLI, American College of Surgeons, October 1996.

16. St. Louis J, Monroe R, Reed RL: Saturation Kinetic Modeling of the Molecular Response to Altered Circulation Using the Michaelis-Menten Equations.  J Trauma Vol 42, 161. 1997.

17. St. Louis J, Hendrickson SC, Kypson AP, Hughes GC, Coleman RE, Donovan CL, Degrado TR, Seabage L, Abdel-aleem S, Landolfo KP, Lowe JE: An Experimental Model of Myocardial Hibernation.  J Am Cardiol 1998; 31: 409A.

18. Hughes GC, Kypson AP, St. Louis JD, Annex BH, Degrado TR, Coleman RE, Lowe JE, Landolfo KP.  Angiogenesis Accompanies Improvement Perfusion in Regions of Hibernating Myocardium Following Transmyocardial Laser Revascularization.  AATS, May 3-6, 1998.

19. St. Louis J, Bannan M, Lutin W, Wiles H: Mitral Valve Pathology Does Not Predict Need For Intervention Or Long-term Survival In Patients With Shone’s Complex. 53rd Southern Thoracic Surgical Association. Nov 8th -11th, 2006

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PRESENTATIONS:

1. St. Louis J, Corcoran PC, Rajan S, Conte J, Wahlstrom T, Wolfinbarger L, Wang YN, Analouei A, Hopkins R: “Biochemical Characterization of Warm Ischemic Injury to Valve Leaflet Fibroblasts in a Porcine Model Using Proton (1H) Magnetic Resonance Spectroscopy”: Annual Scientific Session, The American College of Cardiology, New Orlands, March 1990.

2. St. Louis J, Corcoran PC, Rajan S, Conte J, Wolfinbarger L, Hu L, Lang PL, Wang YN, Hilbert S Analouei A, Hopkins R: “Characterization of the Effects of Warm Ischemia Following Harvesting of Allograft Cardiac Valves by Magnetic Resonance Spectroscopic Analysis of ATP, Phosphorous, Lactate, and Electron Microscopy”: European Society of Thoracic Surgery Annual Meeting, Naples Italy, September 17, 1990.

3. St. Louis J, Lowe J, Hendrickson S, Anstadt M, Perez-Tamayo R, Elbeery J, Landolfo K: “The Duke Clinical Experience With Non-Blood Contacting Biventricular Cardiac Support”: The 3rd Congress of the International Society for Rotary Blood Pumps, Houston Texas, August 27, 1995.

4. St. Louis J, “Current Concepts in Ventricular Assist Devices”: Duke Heart Center Lecture, Durham, North Carolina, September 22, 1995.

5. St. Louis J, “Duke Clinical Experience with Transmyocardial Laser Revascularization”: 22nd Annual Meeting of the Egypt Society of Cardiology, Luxor, Egypt, March 1, 1996.

6. St. Louis J, “Saturation Kinetic Modeling of the Molecular Response to Altered Circulation Using the Michaelis-Menten Equation”: 27th Annual Scientific Meeting of the Western Trauma Association, March 1, 1997.

7. St. Louis J, “An Experimental Model of Myocardial Hibernation”: American College of Cardiology, 1998.

8. St. Louis J, “The ABIOMED BVS System: The Duke Experience”: Brown Medical School Department of Surgery Grand Rounds, Rhode Island Hospital, Providence, RI, May 1, 2002

9. St. Louis J, “Congenital Heart Surgery in the 21st Century”: Pediatric Grand Rounds, Rhode Island Hospital, Providence, RI, August 9, 2002

10. St. Louis J, “Outcomes of Single Ventricle Palliation”: Pediatric Update / Hasbro Symposium.  John Olsen Lectureship, The Westin Hotel, Providence, RI, October 11, 2002

11. St. Louis J, “Conotruncal Syndromes": Clinical Pathological Conference, Women and Infants’ Hospital, Providence, RI, February 19, 2003

12. St. Louis J, “Single Ventricle Palliation: Procedures and Outcomes” Pediatric Cardio and Thoracic Surgery Meeting, South GA Medical Center, Valdosta, GA., March 3, 2004.

13. St. Louis J, “Use of a Carotid Artery Turndown Procedure for Stage One Palliation in a Patient with  Mitral Atresia, Situs Ambiguus, and Interrupted Aortic Arch” First Joint Meeting of the Congenital Heart Surgeons Society and The European Congenial Heart  Surgeons Association, Omni Mont-Royal Hotel, Montreal, Canada, October 2, 2004.

14. St. Louis J, “Surgical Decision Making in the Newborn: How, What, When”, 26th Annual  Neonatology-The Sick Newborn, Savannah, GA, Sept. 30, 2004.

15. St. Louis J, Bannan M, Lutin W, Wiles H : Mitral Valve Pathology Does Not Predict Need For Intervention Or Long-term Survival In Patients With Shone’s Complex. 53rd Southern Thoracic Surgical Association. Nov 8th 11th 2006.

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