Curriculum Vitae
Ashok K. Saluja, Ph.D.

EDUCATION:

1973 B.Sc. (Hons) Punjab Agricultural University; Punjab, India
1975 M. Sc. (Hons) Punjab Agricultural University, Punjab, India
1980 Ph.D. Washington State University (Biochemistry); WA

Postdoctoral Training

1980 Research Fellow, Biochemistry, Washington State University
1981-1982 Research Associate, Biochemistry, Cornell University

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ACADEMIC APPOINTMENTS:

1975-1980 Teaching/Research Assistant, Washington State University
1982-1984 Research Associate in Surgery, Harvard Medical School
1984-1988 Instructor in Surgery (Biochemistry), Harvard Medical School
1988-2001 Assistant Professor of Surgery (Biochemistry), Harvard Medical School, Boston MA
2001-2002 Associate Professor, Harvard Medical School, Boston MA
2003-2006 Professor of Surgery, Medicine and Cell Biology, University of Massachusetts Medical School
2006- Professor and Vice Chair of Research, Department of Surgery, University of Minnesota, Minneapolis, MN

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HOSPITAL APPOINTMENTS:

1982-1984 Fellow in Surgery, Beth Israel Hospital, Boston, MA
1985-2002 Staff Scientist, Beth Israel Deaconess Medical Center, Boston, MA
1989-2002 Director, The Pancreas Research Group, Department of Surgery, Beth Israel Deaconess Medical Center, Boston, MA
2001-2002 Mentor for Young Surgical Faculty, Department of Surgery, Beth Israel Deaconess Medical Center, Boston MA
2003- Director, Pancreatic Diseases Center, University of Massachusetts Medical School, Worcester MA
2004 Member, Cancer Center, U Mass Medical School

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OTHER PROFESSIONAL AND MAJOR VISITING APPOINTMENTS:

1989 Visiting Professor, Yale University
1989 Visiting Professor, Punjab Agricultural University, India
1989 Visiting Professor, University of Ulm, Germany
1993 Visiting Professor, Washington State University, Pullman, WA
1997-1999 Scientific Consultant, Icos Corporation, Bothell, WA
1997 Visiting Professor, W. Wilhelms University, Munster, Germany
1997 Visiting Professor, Essen University, Essen, Germany
1998 Visiting Professor, University of Texas Medical Branch, Galveston, TX
1998 Consultant, Genetics Institute, Andover, MA
2000 Visiting Professor, W. Wilhelms University, Munster, Germany
2001 Visiting Professor, University of Arkansas
2002 Consultant, Hybridon, Inc., Cambridge, MA
2002 Visiting Professor, University of Michigan, Ann Arbor, MI
2003 Visiting Professor, University of Iowa
2004 Visiting Professor PGIMER, Chandigarh, India
2005 Visiting Professor, University of Griefswald, Germany
2006 Visiting Professor, UTMB, Galveston, TX

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MAJOR ADMINISTRATIVE RESPONSIBILITIES:

1985-1988 Supervisor, The Pancreatic Research Laboratory, Beth Israel Hospital, Boston, MA
1989-2002 Director, The Pancreas Research Group, Beth Israel Deaconess Medical Center, Boston, MA
1989-1991 Organizer, Dana-8 Research Forum, Beth Israel Hospital
2003-2006 Director, Pancreatic Diseases Center, University of Massachusetts Medical School

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MAJOR COMMITTEE ASSIGNMENTS:

1978-1979 Selection Committee for Dean of Sciences, Washington State University, Pullman, WA
1990- Ad hoc Reviewer for VA Merit Review Board
1995-1996 Executive Committee for Prepare-21, Beth Israel Hospital
1995-1998 Committee to Oversee Research Computing, Beth Israel Deaconess Medical Center
2000-2002 Institutional Animal Care and Use Committee, Beth Israel Deaconess Medical Center
2000-2002 Scientific Advisory Committee for the Department of Surgery, Beth Israel Deaconess Medical Center
2001-2002 Chair, Faculty Development Committee for Ph.D. Scientists
2002- Ad hoc Reviewer for NIH GMA-2/3 Study Section
2002 Ad hoc Reviewer for NIAAA Special Study Section
2003-2006 Chair, IACUC, UMass Medical School
2005 Organized and directed APA/NPF Symposium on Inflammation and pain in pancreatic diseases in Chicago

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PROFESSIONAL SOCIEITIES:

1979- Member, Society of Sigma Xi, the Scientific Research Society
1983- Member, The American Academy for the Advancement of Science
1983- Member, American Pancreatic Association
1986- Member, Gastroenterology Research Group
1987- Member, American Physiological Society
1988- Member, American Gastroenterological Association (AGA)
1991- Member, American Society of Cell Biology
1995 Abstract Review Committee, (AGA)
2000- Councilor, American Pancreatic Association
2002- Chair, Abstract Review Committee, AGA
2002 Chair, Nomination Committee, Amer Panc Assoc
2004-2005 President, American Pancreatic Association

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EDITORIAL BOARDS:

1986- Gastroenterology, Ad hoc Reviewer
1987- American Journal of Physiology, Ad hoc Reviewer
1988- Pancreas, Ad hoc Reviewer
1992- Journal of Clinical Investigation, Ad hoc Reviewer
1993- International Journal of Pancreatology, Ad hoc Reviewer
1998- Surgery, Ad hoc Reviewer
1998- Member, Editorial Board, Pancreas
1999- American Journal of Pathology, Ad hoc Reviewer
2000- FASEB Journal, Ad hoc Reviewer
2001- Journal of Biological Chemistry, Ad hoc Reviewer
2002- Member, Editorial Board, Pancreatology
2003- Editorial Board, World Journal of Gastroenterology

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AWARDS AND HONORS:

1970-1973 University Merit Scholarship of the Punjab Agricultural University, India

1973-1975 Senior Research Fellowship, Government of India
1978 Fraush Foundation Fellowship

1986 Invited Speaker, during workshop on pancreatitis organized as part of American Pancreatic Association meeting in Chicago, IL, entitled ‘Role of Lysosomes during Pancreatitis’

1990 International Symposium on Pancreatitis, Marburg, Germany: chaired abstract selection committee and session moderator

1990 Invited State of the Art Lecture at the World Congress of Gastroenterology, Sydney, Australia, entitled ‘ Pathogenesis of Acute Pancreatitis”

1990 Invited Speaker and Session Chair at International Pancreatic Association meeting in Nagasaki, Japan, entitled, “Pathophysiology of Acute Pancreatitis”

1992 Gastroenterology Symposium, Amsterdam, The Netherlands: Invited Speaker, “Etiopathology of Pancreatitis”

1996 Invited State of the Art lecture at the Frontiers in Pancreatic Physiology Conference, Chicago, IL entitled, “Cellular Events Leading To Digestive Enzyme Activation During Acute Pancreatitis”

1997 Invited Presentation, First Conference on Hereditary Diseases of the Pancreas, Pittsburgh, PA. “Role Of Activated Zymogens In Pancreatitis”

1997 Workshop on the Role of Cytokines in Pancreatic Diseases, Chicago, IL. Invited Speaker, “Role of PAF in Pancreatic Inflammation”

1998 Invited State of the Art Speaker at International Association of Pancreatology, Tokyo, Japan: “New Approaches for the Management of Acute Pancreatitis: Role of Cytokines” and Session Chairman.

1998 Invited Speaker, German Digestive Diseases meet ing, Kiel, Germany: “Therapeutic Effects of PAF-Acetyl Hydrolase in Severe Acute Pancreatitis”

1999 European Pancreas Club, Luneburg, Germany, Invited State of the Art presentation entitled “Cytokines and Chemokines in Pancreatitis — Multiple Players and a Single Goal” and Chairperson to select the best poster presentation.

2000 Invited Presentation during European Pancreatic Club Meeting in Kiel, Germany, entitled, “ Heat Shock Proteins and Pancreatitis”

2000 Organized and moderated a focus group on NIH funding in pancreatic research during American Pancreatic Association Meeting in Chicago, IL

2000 State of the Art Presentation at Indian Society of Gastroenterologists, New Delhi, India, entitled “Pathophysiology of Acute Pancreatitis”

2001 Invited Presentation during the Japan Pancreas Society meeting in Kitakyushu, Japan, entitled, “Recent Progress in the mechanism of Acute Pancreatitis”

2002 Invited State of the Art Presentation “Colocalization during Pancreatitis- Truth or Fiction” during European Pancreatic Club/ International Association meeting in Heidelberg, Germany.

2002 NIAAA Symposium “Mechanisms of Alcoholic Pancreatitis” in Chicago, IL, Discussion Leader.

2003 Invited symposium Speaker “Heat Shock Proteins and Pancreatitis” European Pancreas Club meeting in Liverpool, UK

2003 Invited State of the Art talk "Acinar Cell Response to Stress in Acute Pancreatitis" during Dig Dis Week, Orlando

2003 Invited Speaker “Pathophysiology of Pancreatitis” during “Frontiers in Epithelial Transport 2004” in Seoul, South Korea

2005 Guest Lecture “Newer insights in the pathogenesis of acute of acute pancreatitis” during 1st Anuual Conference of Indian Pancreas Club, New Delhi, India

2005 Invited Lecture “Activation of Trypsinogen in aciner cells during pancreatitis during International Symposium on Pancreatic diseases, Munich, Germany

2005 “Time of Change” Presidential Address, American Pancreatic Association

2006 Invited State-of-the-Art Lecture; “ TLRs and Pancreatitis” European Pancreas Club meeting in Finland (June)

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FUNDING INFORMATION:

Current

2006-2111 PENDING--NCI (RO1 CA 124723) “Inhibition of HSP70 Induces Apoptosis in Pancreatic Cancer Cells”
2001-2007 NIDDK (RO1-58694) Heat Shock Proteins and Pancreatitis (PI)
2005-2007 NIDDK (R21) Pathogenesis of Arginine-induced Pancreatitis (PI)
2005-2006 Oscar Pluznick Foundation grant, HSP in Pancreatic Cancer
2006-2007 Thomas Pappas Foundation Grant for Pancreatic Research

Past

1983-2007 NIDDK(31396) Acute pancreatitis (Co-PI)
2001-2002 Bayer Corporation Study of efficacy of α-2 Macroglobulin against acute pancreatitis in the opossum model (PI)
2002-2003 Signal Pharma Role of JNK inhibitors in Pancreatitis (Co-PI)
2002 Hybridon, Inc. Immune modulation by oligonucleotides (PI)
1993-1997 NIDDK(46331) Signal Transduction in Pancreatic Acinar Cells (Co-PI)
1997-2000 ICOS corporation Efficacy of rPAF-AH in Acute Pancreatitis (Co-PI)
1998-1999 Genetics Institute Role of IL-11 in Acute Pancreatitis (PI)

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CURRENT RESEARCH INTERESTS:

1. Physiology and Cell Biology of Pancreas: Stimulus-Secretion Coupling (intracellular signal transduction)
2. Etiology and Pathophysiology of Acute and Chronic Pancreatitis in Animal Models.
3. Mechanisms of premature intra-acinar cell activation of digestive enzyme zymogens.
4. Alterations of intracellular calcium homeostasis in pancreatitis and pancreatic cancer.
5. Role of Inflammatory agents in determining the severity of pancreatitis.
6. Relationship between pancreatitis and lung injury
7. Role of Protease Activated Receptors (PARs) in pancreatitis.
8. Heat shock proteins and their role in pancreatitis: How do HSPs prevent pancreatitis?
9. Pathophysiology of alcohol-induced pancreatic injury.
10. Role of heat shock proteins in pancreatic cancer.

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TEACHING ACTIVITIES:

Local Contributions

1975-1980 Teaching Assistant and Tutor for General and Organic Chemistry and Biochemistry courses at Washington State University, Pullman, WA

1985-2002 Harvard Medical School and Beth Israel Deaconess Medical Center: As director of the Pancreas Research Group, I am responsible for teaching and training undergraduate and graduate students and research fellows and post-doctoral associates who are part of our group. Typically I have 4 to 6 such trainees. Most of them have no prior knowledge in the areas of pancreatitis and many times have no experience in research. My main task is to teach them research methodology and train them in a variety of biochemical, cell biological, and histological techniques. I also teach the students and fellows in the group how to analyze data, interpret and present their experimental findings and write and prepare manuscripts.

2002- Teaching and training undergraduate and graduate students and research fellows, Surgical Residents and post-doctoral associates

2002 Faculty participant, Integrated Human Physiology, HMS

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LIST OF ADVISEES AND TRAINEES:

1984-1985 Peter Rutledge, M.D., Private Practice, Dallas, TX
1986-1987 Gakuji Ohshio, M.D., Staff Surgeon, Kyoto, Japan
1987-1988 T. Hirano, M.D., Associate Professor, Kyoto University, Kyoto, Japan
1988-1990 Markus Lerch, M.D., Professor and Chair, Department of Gastroenterology, W. Wilhelms University, Munster, Germany
1989-1991 P.Ramarao, Ph.D., Associate Professor, Banaras Hindu University, Banaras, India
1991-1994 R.K. Dawra, Ph.D., Senior Scientist, IVRI, Palampur, India
1991-1993 Michael Runzi, M.D., Professor, University of Essen, Essen, Germany
1993-1994 T. Grady, Ph.D., Medical Resident, Michigan
1994-1995 Li Lu, M.D., Ph.D., Pathologist, Tampa, FL
1995-1997 Bernd Hofbauer, M.D., Surgical Resident, Stuttgart, Germany
1997-1999 Madhav Bhatia, Ph.D., Assistant Prof of Pharmacology, Singapore
1998-2000 H.S. Lee, M.D., Associate Professor, Seoul, Korea
1998-2000 Jean-Louis Frossard, M.D., Assistant Prof of gastroenterology, Geneva, Switzerland
1997-2002 Lakshmi Bhagat, Ph.D., Senior Scientist, Hybridon, Inc., Cambridge, MA
1998-2000 Antti Hietaranta, M.D., Surgeon, Helsinki, Finland
1998-2002 Vijay Singh, M.D., GI Fellow, Mayo Clinic
1999-2001 Albert Song, M.D., Surgeon, Los Angles, CA
1999-2001 Andreas Mykoniatis, M.D., Surgical Resident, Cincinnati, OH
2000-2001 Gijs van Acker, M.D., Medical Resident, Amsterdam
2002- Rifat Sharif, M.D., Research Fellow, U Mass Med School
2002- Rajinder Dawra, Ph.D., Research Assistant Professor, U Mass Med School
2002-2003 Yang Sha Ku, M.D., Associate professor of Medicine, Korea
2002-2004 Dhara Dhaulakhandi, Research Fellow, U Mass Med School
2003-2004 Ali Aghdassi, Research Fellow, U Mass Medical School
2004-2005 Marvin Morris, Surgical Resident, U Mass Medical School
2005-2006 Phoebe Phillips, Post Doctoral Fellow, UMass Medical School
2005-2006 Vikas Dudeja, Research Fellow, UMass Med School

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INVITED PRESENTATIONS:

Local

1987 Research Seminar, “Pathophysiology of Acute Pancreatitis” Northeastern University, Boston, MA

1988 GI Grand Rounds, “New Insights in to Pathogenesis of Pancreatitis” Roxbury VA Hospital, Boston, MA

1989 Surgical Grand Rounds, “How and Where Acute Pancreatitis Begins” MGH, Boston, MA

1990 Dana-8 Research Forum, “New Developments in Acute Pancreatitis”, Beth Israel Hospital, Boston, MA

1991 Surgical Research Seminar, “Role of Activated Enzymes in the Pathogenesis of Acute Pancreatitis” BIH, Boston, MA

1992 Harvard Digestive Diseases Center, “Stimulus-Secretion Coupling in Pancreatic Acinar Cells”, HMS, Boston, MA

1993 Surgical Grand Rounds, “Pathogenesis of Acute Pancreatitis”, BIH, Boston, MA

1994 GI Research Rounds “Signal Transduction in Acinar cells: What is True and What is not”, MGH, Boston MA

1996 “Pathophysiology of acute Pancreatitis” Surgery Research Seminar, BIDMC, Boston MA

1997 GI Research Seminars, “Some New Insights into the Pathogenesis of Acute Pancreatitis”, BIDMC, Boston, MA

2001 Surgical Research Seminar, “Pathogenesis of Pancreatitis- Role of  Cytokines, HSPs and other Culprits”, BIDMC, Boston

2001 “Role of Heat Shock proteins in Pancreatitis”, GI Seminars, BIDMC, Boston MA

2003 "Role of Trypsinogen Activation and Stress Proteins in Pancreatitis" Tupper Seminar Series, Tufts-New England Medical Center, Boston MA

2003 "Role of Trypsinogen Activation and Heat Shock Proteins in Pancreatitis", Cell Biology Seminars, University of Massachusetts Medical School, Worcester, MA

2003 “Intracellular Calcium and Pathogenesis of Pancreatitis” Seminar in Physiology, University of Massachusetts Medical School

2004 “Pathophysiology of Pancreatitis: Role of Heat shock Proteins”, Distinguished Seminar Series, Department of Molecular Biology, Boston University Medical School

2005 “Pancreatic cancer and Heat Shock Proteins”, GI cancer seminars, University of Massachusetts Medical School

2005 “Heat Shock Proteins as Modulators of pancreatic cancer”, Translational Oncology Lectures, University of Massachusetts Medical School

Regional, National and International

1989 “Pathophysiology of Acute Pancreatitis”, Surgical Grand Rounds, Yale University, New Haven, CT

1990 “Patho-mechanisms of pancreatitis”, Research Seminar, Punjab Agricultural University, Ludhiana, India

1990 “Advances in Pathophysiology of Acute Pancreatitis”, GI Research Seminar, All India Institute of Medical Sciences, New Delhi, India

1991 “Acute pancreatitis: Some insights into Pathogenesis”, Surgery Seminars, University of Ulm, Germany

1993 “Signal Transduction in Acinar Cells”, Biochemistry Research Seminar, Washington State University, Pullman, WA

1997 “Role of PAF in the pathogenesis of severe acute Pancreatitis”, Research Seminar, ICOS Corporation, Bothell, WA

1997 “Hydrolysis of platelet Activating Factor decrease the severity of acute Pancreatitis”, Invited talk, Hamburg, Germany

1997 “Pathogenesis of Pancreatitis: role of Inflammatory mediators”, GI Research Seminar, University of Essen, Germany.

1997 “Role of PAF and other inflammatory mediators in Pancreatitis”, Grand Rounds in Medicine,Muenster, Germany

1998 “Pathophysiology of Pancreatitis: Role of Platelet Activating Factor and Cytokines”, Seminar, UTMB, Galveston, TX

1998 “Efficacy of rPAF-AH in severe acute Pancreatitis”, Research Seminar, Suntory Research Center, Osaka, Japan

1999 Research Seminar, “Pathogenesis of Pancreatitis: Role of Cytokines and rPAF-AH”, Department of Surgery, UCLA, Los Angles, CA

1999 Grand Rounds, “Pathogenesis of Acute Pancreatitis: Role of rPAF-AH and other Inflammatory Mediators”, Surgery, USC, Los Angles, CA

1999 Grand Rounds in Surgery, “Role of Inflammatory Mediators in determining the severity of pancreatitis”, Munich, Germany

1999 Surgical Grand Rounds, “Pathogenesis of Pancreatitis: Role of Inflammatory Mediators”, Stuttgart, Germany

2000 “Mechanisms of Onset of Acute Pancreatitis- the Role of Calcium, Cytokines, Heat Shock Proteins and other Culprits”, Seminars in Medicine, Muenster, Germany

2000 “Pathogenesis of Acute Pancreatitis”, Medical Seminars, Christian Medical College, Ludhiana, India

2000 “Some Recent Insights into Pancreatitis”, Research Seminar, Torrent Research Center, Ahemdabad, India

2001 “Pathogenesis of Acute Pancreatitis”, Surgical Grand Rounds, Sapporo, Japan

2001 Physiology Seminars, Univ. of Arkansas, Little Rock, AR

2002 Seminars in Physiology, Oklahoma University Health Science Center, Oklahoma City, OK

2002 “Pathophysiology of Pancreatitis: Role of Calcium, HSPs, PARs and Other Culprits”, Seminar in Physiology and GI, University of Michigan, Ann Arbor, MI

2002 “Trypsin Activation, Heat Shock Proteins and Pancreatitis” Lectures in Medicine, University of Massachusetts Medical School, Worcester MA

2003 “Pathomechanisms of Acute Pancreatitis”,Surgical Grand Rounds University of Iowa

2003 “Role of Heat Shock Proteins in Pancreatitis”, Seminars in Gastroenterology, All India Institute of Medical Sciences, New Delhi, India

2003 “Heat Shock Proteins and Pancreatic Disorders”, Seminars in Biotechnology, Jawaharlal Nehru University, New Delhi, India

2003 “Role of Premature Trypsinogen Activation in Pancreatitis”, Biochemistry Seminars at University of Delhi, India

2004 “New insights in to Diseases of exocrine pancreas” Medicine Seminars in Bangkok, Thailand

2004 “Pathophysiology of Pancreatitis: What is New ?”, Grand Rounds in PGIMER, Chandigarh, India

2004 “Pathophysiology of Acute Pancreatitis: Some recent insights”, GI Seminars at Northwestern University, Chicago

2005 “Heat Shock Proteins and Pancreatic disorders”, Research Seminars, Locus Pharmaceuticals, Philadelphia

2005 “HSP and Pancreatic Cancer”, during National Conference on Pancreatic Diseases, New Delhi, India

2006 “Role of Heat Shock Proteins in Pancreatic Diseases” seminars in GI, UTMB

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ARTICLES:

1. Saluja AK, McFadden BA. Inhibition of ribulose biphosphate carboxylase/oxygenase by sedoheptulose-1, 7-biphosphate. FEBS Lett 1978; 96(2):361-363.

2. Shively JM, Saluja A, McFadden BA. Ribulose biphosphate carboxylase from methanolgrown Paracoccus denitrificans. J. Bacteriol 1978; 134(3):1123-1132.

3. Saluja AK, McFadden BA. Modification of histidine at the active site of spinach ribulose biphosphate carboxylase. Biochem Biophys Res Commun 1980; 94:1091-1097.

4. Saluja AK, McFadden BA. Modification of active-site histidine in ribulose biphosphate carboxylase oxygenase. Biochemistry 1982; 21:89-25.

5. Berhow MA, Saluja AK, McFadden BA. Rapid purification of D-ribulose 1,5 biphosphate carboxylase by vertical sedimentation of a re-oriented gradient. Plant Sci Lett 1982; 27:51-57.

6. Purohit K, McFadden BA, Saluja AK. Stochiometry in the assay of ribulose biphosphate oxygenase and carboxylase. Anal Biochem 1982; 124:156-166.

7. Powers RE, Johnson PC, Houlihan MJ, Saluja AK, Steer ML. Secretagogue induced changes in intracellular free Ca2+ and amylase secretion in Quin-2 loaded mouse pancreatic acini. Am J Physiol 1985; 248:C533-541.

8. Saluja A, Saito I, Saluja M, Houlihan MJ, Powers RE, Meldolesi J, Steer ML. In-vivo rat pancreatic acinar cell function during experimental stimulation with caerulein. Am J Physiol 1985; 249:G702-710.

9. Gershenwald JE, Bensadoun A, Saluja A. Monoclonal antibodies to avian lipoprotein lipase. Purification of the enzyme by immunoaffinity chromatography. Biochim Biophys Acta 1985; 836: 286-295.

10. Powers RE, Saluja AK, Houlihan MJ, Steer ML. Inositol trisphosphate production and amylase secretion in mouse pancreas. Biochem Biophys Res Commun 1985; 131:286- 288.

11. Saluja A, Saluja M, Powers RE, Houlihan MJ, Steer ML. Failure of extracellular digestive systems to alter in-vitro secretion by rat pancreas. Am J Physiol 1986; 250:C413-417.

12. Powers RE, Saluja AK, Houlihan MJ, Steer ML. Diminished agonist-stimulated inositol triphosphate generation blocks stimulus-secretion coupling in mouse pancreatic acini during diet-induced experimental pancreatitis. J Clin Invest 1986; 77:1668-1674.

13. Rutledge PL, Saluja AK, Powers RE, Steer ML. Role of oxygen-derived free radicals in dietinduced pancreatitis in mice. Gastroenterology 1987 93:41-47.

14. Saluja AK, Saluja M, Powers RE, Houlihan MJ, Steer ML. Subcellular redistribution of lysosomal enzymes during caerulein-induced pancreatitis. Am J Physiol 1987; 253:G508-516.

15. Saito I, Hashimoto S, Saluja A, Steer ML, Meldolesi J. Intracellular transport of pancreatic zymogens during supramaximal stimulation with caerulein. Am J Physiol 1987; 253:G517-526.

16. Rutledge PL, Saluja A, Leli U, Steer ML. A simple and efficient method of measuring in-vitro amylase secretion by dispersed pancreatic acini. Pancreas 1988; 3:508-511.

17. Ohshio G, Saluja A, Leli U, Sengupta A, Steer ML. Failure of a potent cholecystokinin antagonist to protect against diet-induced acute experimental pancreatitis in mice. Pancreas 1989; 4:739-743.

18. Saluja A, Saluja M, Villa A, Leli U, Rutledge P, Meldolesi J, Steer M. Pancreatic duct obstruction in rabbits causes digestive zymogen and lysosomal enzyme colocalization. J Clin Invest 1989; 84:1260-1266.

19. Ohshio G, Saluja AK, Leli U, Sengupta A, Steer ML. Esterase inhibitors prevent lysosomal enzyme redistribution in two noninvasive models of experimental pancreatitis. Gastroenterology 1989; 96:853-859.

20. Saluja AK, Saluja M, Printz H, Zavertnik A, Sengupta A, Steer ML. Experimental pancreatitis is mediated by low affinity CCK receptors which inhibit digestive enzyme secretion. Proc Natl Acad Sci USA 1989; 86:8969-8971.

21. Printz H, Saluja A, Leli U, Sengupta A, Steer ML. Effects of hemorrhagic shock, aspirin, and ethanol on secretagogue-induced experimental pancreatitis. Int J Pancreatol 1990; 6:207- 217.

22. Saluja AK, Powers RE, Steer ML. Inositol trisphosphate independent increase of intracellular free calcium and amylase secretion in pancreatic acini. Biochem Biophys Res Commun 1989; 164:8-13.

23. Leli U, Saluja A, Picard L, Zavertnik A, Steer ML. Effects of a choline-deficient ethioninesupplemented diet of phospholipase C activity in mouse pancreatic acinar cell membranes and electro-permeabilized mouse pancreatic acini. J Pharmacol Exp Ther 1990; 253:847-850.

24. Ohshio G, Saluja A, Steer ML. Effects of short-term duct obstruction in rats. Gastroenterology 1990, 100:196-202.

25. Saluja M, Saluja A, Lerch MM, Steer ML. A plasma esterase which is expressed during supramaximal stimulation causes in vitro subcellular redistribution of lysosomal enzymes in rat exocrine pancreas. J Clin Invest 1991; 87:1280-1285.

26. Hirano T, Saluja A, Ramarao P, Lerch M, Saluja M, Steer ML. Apical secretion of lysosomal enzymes in rabbit pancreas occurs via a secretagogue regulated pathway and is increased after pancreatic duct obstruction. J Clin Invest 1991;87:865-869.

27. Hirano T, Saluja A, Ramarao P, Lerch MM, Steer ML. Effects of chloroquine and methylamine on lysosomal enzyme secretion by rat pancreas. Am J Physiol 1992;262:G439-444.

28. Lerch MM, Saluja AK, Dawra R, Ramarao P, Saluja M, Steer ML. Acute necrotizing pancreatitis in the opossum: earliest morphologic changes involve acinar cells. Gastroenterology 1992:103;205-213.

29. Lerch MM, Saluja AK, Dawra R, Saluja M, Steer ML. The effect of chloroquine administration on two experimental models of acute pancreatitis. Gastroenterology 1992. 103: 1768-1779.

30. Saluja AK, Dawra RK, Lerch MM, Steer ML. CCK-JMV-180, an analog of cholecystokinin, stimulates intracellular calcium release from an IP3-independent pool in rat pancreatic acini. J Biol Chem 1992. 287:11202-11207.

31. Grady T, Saluja AK, Steer ML, Lerch MM, Modlin IM, Powers RE. In vivo and in vitro effects of the azidothymidine analog dideoxyinosine on the exocrine pancreas of the rat. J Pharmacol Exp Ther 1992; 262:445-449.

32. Hirano T, Manabe T, Printz H, Saluja A, Steer M. Secretion of lysosomal and digestive enzymes into pancreatic juice under physiological and pathological conditions in rabbits. Nippon Geka Hokan 1992; 61:103-124.

33. Steer ML, Rutledge PL, Powers RE, Saluja M, Saluja AK. The role of oxygen-derived free radicals in two models of experimental acute pancreatitis: effects of catalase, superoxide dismutase, dimethylsulfoxide, and allopurinol. Klin Wochenschr 1991; 69:1012-1017.

34. Runzi M, Saluja A, Lerch MM, Da wra R, Nishino H, Steer ML. Early ductal decompression prevents the progression of biliary pancreatitis: An experimental  study in the opossum. Gastroenterology 1993;105:157-164.

35. Dawra RK, Saluja A, Runzi M, Steer ML. Inositol trisphosphate-independent agoniststimulated. Calcium influx in rat pancreatic acinar cells. J Biol Chem 1993;268:20237-20242.

36. Hirano T, Manabe T, Saluja AK, Steer ML. Pancreatic secretion of lysosomal enzymes stimulated by intraduodenal instillation of a liquid meal in rabbits. Clin Sci (Colch) 1992; 83:277-280.

37. Lerch MM, Saluja AK, Runzi M, Dawra R, Saluja M, Steer, ML. Pancreatic duct obstruction triggers acute pancreatitis in the opossum. Gastroenterology 1993;103:1768-1779.

38. Dawra RK, Saluja A, Lerch MM, Saluja M, Logsdon C, Steer ML. Stimulation of pancreatic growth by cholecystokinin is mediated by low affinity receptors on rat pancreatic acinar cells. Biochem Biophys Res Commun 1993; 193: 814-820.

39. Baba Y, Lerch MM, Tanimoto A, Kreft BP, Saluja AK, Zhao L, Chen J, Steer ML Stark DD. Enhancement of pancreas and diagnosis of pancreatitis using manganese dipyridoxyl diphosphate. Invest Radiol 1994;29: 300.

40. Baba Y, Lerch MM, Stark DD, Tanimoto A, Kreft BP, Zhao L, Saluja AK, Takahashi M. Time after excision and temperature alter ex vivo tissue relaxation time measurements. J Magn Reson Imaging 1994;4: 647-51.

41. Runzi M, Raptopoulos V, Saluja AK, Kaiser AM, Nishino H, Gerdes D, Steer ML. Evaluation of necrotizing pancreatitis in the opossum by dynamic contrast-enhanced computerized tomography. J Am Coll Surg 1995;180:673-682.

42. Runzi M, Saluja A, Kaiser A, Gerdes D, Sengupta A, Steer ML. Biochemical and morphological changes that characterize recovery from necrotizing pancreatitis in the opossum. Gut 1995;37:427-433.

43. Fallon MB, Gorelick FS, Anderson JM, Mennone A, Saluja A, Steer ML. Effect of caerulein hyperstimulation on the paracellular barrier of rat exocrine pancreas. Gastroenterology. 1995;108:1863-1873.

44. Lerch MM, Saluja AK, Runzi M, Dawra R, Steer ML. Luminal endocytosis and intracellular targeting by acinar cells during early biliary pancreatitis in the opossum. J Clin. Invest 1995;95:2222-2231.

45. Kaiser AM, Saluja AK, Sengupta A, Saluja M, Steer ML. Relationship between severity, necrosis and apoptosis in five models of experimental acute pancreatitis. Am J Physiol 1995; 38:C1295-1304.

46. Grady T, Saluja A, Kaiser A, and Steer M. Edema and intrapancreatic trypsinogen activation precede glutathione depletion during caerulein pancreatitis. Am J Physiol 1996; 271:G20-26.

47. Kaiser AM, Saluja AK, Lu L, Yamanaka K, Yamaguchi Y, Steer ML: Effects of cycloheximide on pancreatic endonuclease activity, acinar cell apoptosis, and the severity of acute pancreatitis. Am J Physiol 1996; 40:982-989.

48. Saluja A, Hofbauer B, Yamaguchi Y, Yamanaka K, and Steer M. Induction of apoptosis reduces the severity of caerulein-induced pancreatitis in mice. Biochem Biophys Res Commun 1996; 220: 875-878.

49. Yamanaka K, Saluja AK, Brown GE, Yamaguchi Y, Hofbauer B, Steer ML. Protective effects of prostaglandin E1 on acute lung injury of caerulein-induced acute pancreatitis in rats. Am J Physiol 1997; 272: G23-G30.

50. Saluja AK, Donovan EA, Yamanaka K, Yamaguchi Y, Hofbauer B, Steer ML. Caeruleininduced in vitro activation of trypsinogen in rat pancreatic acini is mediated by cathepsin B. Gastroenterology 1997;113:304-310

51. Saluja AK, Lu L, Yamaguchi Y, Hofbauer B, Runzi M, Dawra R, Bhatia M, Steer ML. A cholecystokinin-releasing factor mediates ethanol-induced stimulation of rat pancreatic secretion. J Clin Invest 1997;99:506-512.

52. Gerard C, Frossard J-L, Bhatia M, Saluja A, Gerard NP, Lu B, Steer M. Targeted disruption of the β-chemokine receptor CCR1 protects against Pancreatitis-associated lung injury. J Clin Invest 1997, 100:2022-2027

53. Bhatia M, Saluja AK, Hofbauer B, Frossard J-L, Lee HS, Castagliuolo I, Wang CC, Gerard N, Pothoulakis C, Steer ML. Role of substance P and neurokinin1 receptor in acute pancreatitis and pancreatitis-associated lung injury. Proc Natl Acad Sci USA 1998, 95: 4760-4765.

54. Hofbauer B, Saluja AK, Lerch MM, Bhagat L, Bhatia M, Lee HS, Frossard J-L, Adler G, Steer ML. Intra-acinar cell activation of trypsinogen during caerulein-induced pancreatitis in rats. Am J Physiol 1998;275:G352-362.

55. Hofbauer B, Saluja AK, Bhatia M, Frossard J-L, Lee HS, Bhagat L, Steer ML. Effect of recombinant platelet activating factor acetylhydrolase on two models of experimental acute pancreatitis. Gastroenterology 1998;115:1238-1247.

56. Bhatia M, Wallig MA, Hofbauer B, Lee HS, Frossard J-L, Steer ML, Saluja AK. Induction of apoptosis in pancreatic acinar cells reduces the severity of acute pancreatitis. Biochem Biophys Res Commun 1998, 246: 476-483.

57. Bhatia M, Saluja AK, Hofbauer B, Lee HS, Frossard J-L, Steer ML. The effects of neutrophil depletion on a completely noninvasive model of acute pancreatitis- associated lung injury. Int J Pancreatol 1998, 24: 77-83.

58. Frossard J-L, Saluja AK, Bhagat L, Lee HS, Bhatia M, Hofbauer B, Steer ML. The role of intercellular adhesion molecule 1 and neutrophils in acute pancreatitis and pancreatitis associated lung injury. Gastroenterology 1999; 116:694-701.

59. Saluja AK, Bhagat L, Lee HS, Bhatia M, Frossard J-L, Steer ML. Secretagogue-induced digestive enzyme activation and cell injury in rat pancreatic acini. Am J Physiol 1999; 276:G835-842.

60. Kaiser A, Saluja AK, and Steer. Repetitive short-term obstruction of the common bilepancreatic duct induces severe acute pancreatitis in the opossum. Dig Dis Sci 1999, 44:1653-61.

61. Bhagat L, Singh VP, Hietaranta AJ, Agrawal S, Steer ML, Saluja AK. Heat shock protein 70 prevents secretagogue-induced cell injury in the pancreas by preventing intra-cellular trypsinogen activation. J Clin Invest 2000; 106:81-89.

62. Lee HS, Bhagat L, Frossard J-L, Hietaranta AJ, Singh VP, Steer ML, Saluja AK. Relationship between water immersion stress, expression of heat shock prote in 60, and protection against secretagogue-induced pancreatitis. Gastroenterology 2000; 119:220- 229.

63. Gao Y, Lecker S, Post MJ, Hietaranta AJ, Li J, Volk R, Li M, Sato K, Saluja AK, Steer ML, Goldberg AL, Simon M. Inhibition of ubiquitin- proteasome pathway mediated I kappa B alpha degradation by a naturally occurring antibacterial peptide. J Clin Invest 2000, 106:439-448.

64. Hietaranta AJ, Saluja AK, Bhagat L, Singh VP, Song AM, Steer ML. Relationship between NF-κB and trypsinogen activation in rat pancreas after supramaximal caerulein stimulation. Biochem Biophys Res Commun 2001, 280:388-395.

65. Bhatia M, Saluja AK, Singh, VP, Frossard JL, Lee HS, Bhagat L, Gerard C, Steer ML. Complement factor C5a exerts an anti-inflammatory effect in acute pancreatitis and pancreatitis-associated lung injury. Am J Physiol 2001, 280: G974-978.

66. Hietaranta AJ, Singh VP, Bhagat L, Song AM, Mykoniatis A, van Acker GJD, Steer ML, Saluja AK. Water immersion stress prevents caerulein-induced pancreatic acinar cell NF- κB activation by attenuating caerulein-induced intracellular Ca2+ changes. J Biol Chem 2001, 276:18742-7.

67. Singh VP, Saluja AK, Bhagat L, Hietaranta AJ, Song A, Mykoniatis A, van Acker GJD, and Steer ML. Serine protease inhibitors cause F-actin redistribution and inhibition of calcium-mediated secretion in pancreatic acini. Gastroenterology 2001, 120:1818-27.

68. Singh VP, Saluja AK, Bhagat L, van Acker GJD, Song AM, Soltoff SP, Cantley LC and Steer ML. Phosphatidylinositol-3-kinase plays a critical role in mediating intrapancreatic activation of trypsinogen and regulating the severity of acute pancreatitis. J Clin Invest 2001,108:1387-1395.

69. Frossard JL, Lee HS, Bhagat L, Hietaranta AJ, Singh VP, Steer ML, Saluja AK. Thermal and non-thermal stress protects against caerulein-induced pancreatitis by preventing trypsinogen activation in the pancreas. Gut 2002, 50:78-83.

70. Bhagat L, Singh VP, Song AM, van Acker GJD, Agrawal S, Steer ML, Saluja AK. Heat shock protein 70 mediates protection against secretagogue-induced intra-pancreatic trypsinogen activation and acute pancreatitis after thermal stress. Gastroenterology 2002;122:156-165.

71. Frossard JL, Saluja AK, Mach N, Lee HS, Bhagat L, Hadengue A, Dranoff G, Steer ML. In vivo evidence for the role of GM-CSF as a mediator in acute pancreatitis-associated lung injury. Amer J Physiol 2002; 283: L542-548.

72. Song A, Bhagat L, Singh V, van Acker G, Steer M and Saluja A. Inhibition of cyclooxygenase (COX-2) ameliorates the severity of pancreatitis and associated lung injury. Amer J Physiol 2002; 283: G1166-74.

73. Gijs J.D. van Acker, Ashok K. Saluja, Lakshmi Bhagat, Vijay P. Singh, Albert M. Song and Michael L. Steer. The Cathepsin B inhibitor CA-074 prevents intrapancreatic trypsinogen activation and reduces severity of pancreatitis. Amer J Physiol 2002; 283: G794-800.

74. Saluja A, Bhagat L. Pancreatitis and associated injury: When MIF Miffs. Gastroenterology 124: 844-847, 2003

75. Saluja A and Bhagat L. Pathophysiology of alcohol-induced pancreatic injury. Pancreas 27: 327-331, 2003.

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MANUSCRIPTS SUBMITTED OR IN PREPARATION:

1. Sharif R, Dawra R, Dhaulakhandi D, Ku YS, Kurt-Jones E, Finberg R and Saluja A. Deletion of TLR-4 receptors ameliorates the severity of caerulein-induced Pancreatitis.

2. Bhagat L, Dawra R, Dhaulakhandi D, Ku YS, Sharif R, Garg L and Saluja A. Transgenic overexpression of heat shock protein 70 protects against secretagogue-induced Pancreatitis.

3. Ku YS, Sharif R, Dhaulakhandi D, Dawra R, Bhagat L and Saluja A. Inhibition of poly (ADP-ribose) polymerase attenuates the severity of caerulein-induced Pancreatitis and associated lung injury by inhibition of NFκ-B activation.

4. Pothoulakis C, Saluja M, Anton P, Pan A, Dawra R, Garg L, Blueher S, Mantzoros C, and Saluja AK. Leptin plays an anti-inflammatory role in acute Pancreatitis.

5. Bhagat L,Singh VP, and Saluja AK. Arsenite, a non-thermal stressor, induces hsp70 expression in the pancreas and protects against secretagogue-induced Pancreatitis by preventing trypsinogen and NF-κB activation.

6. Dhaulakhandi D, Bhagat L, Dawra R and Saluja A. Deletion of HSF-1 prevents stressinduced expression of HSP 70 and exacerbate severity of pancreatitis.

7. Dawra R, Sharif R, Dhaulakhandi D and Saluja A. Glutathione deletion prevents digestive enzyme secretion in response to secretagogues and inhibits pancreatitisinduced trypsinogen activation in Pancreatic Acinar cells.

8. Dawra R,Sharif R, and Saluja A. – Characterization of Arginine induced model of pancreatitis in mice.

9. Singh V., Bhagat L, Navina S, Dawra R and Saluja A. PAR-2 ameliorate pancreatitis by stimulating digestive enzyme secretions from pancreatic acinar cells.

10. Aghdassi A, Phillips P, Sharif R, Dawra R, Lerch M, and Saluja A. Depletion of Heat Shock Protein-70 Causes Apoptosis in Pancreatic Cancer Cells.

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REVIEWS, CHAPTERS AND EDITORIALS:

1. Steer ML, Saluja AK, Meldolesi J. The cell biology of acute pancreatitis. In: Thompson JC, editor. Gastrointestinal endocrinology: receptors and post-receptor mechanisms. San Diego: Acad. Press; 1990. p. 397-406.

2. Steer ML, Saluja AK. Etiology and pathogenesis of acute pancreatitis. In: Surgery for pancreatic diseases. Springer Verlag, 1992.

3. Steer ML, Saluja AK. Experimental acute pancreatitis: Studies of the early events that lead to cell injury. In: Go VLW, DiMagno EP, Gardner JD, Lebenthal E, Reber HA, Scheele GA,

editors, The Pancreas: Biology, Pathophysiology, and Disease, 2nd Edition. New York: Raven Press; 1993. p. 489-500.

4. Steer ML, Saluja AK. Lysosomal enzymes and pancreatitis. Gastroenterology 1996;110:965-967.

5. Steer ML, Saluja AK. Pathogenesis and pathophysiology of acute pancreatitis. In: Beger HG, Warshaw AL, Buchler MW, Carr-Lockes DL, Neoptolemos JP, Russell C, Sarr MG, editors, The Pancreas, Vol 2. London: Blackwell Science Ltd. 1998; p.383-391.

6. Saluja AK, Steer ML. Pathophysiology of pancreatitis: Role of cytokines and other mediators of inflammation. Digestion 1999, 60:27-33.

7. Wassef W and Saluja A. Chemokines and Clinical Pancreatitis. Pancreatology (invited editorial) 2004

8. Saluja A. and Bhagat L. Experimental models of acute pancreatitis. Accepted for publication in Encyclopedia of Gastroenterology 2003

9. Andersen DK, Bell RH, Brunicardi FH, Fisher WE and Saluja AK. The Pancreas. In the textbook of Surgery. 2004

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THESIS:

Saluja AK. Mechanism of action of acetylcholinesterase. M.Sc.(Hons) thesis. Ludhiana, India: Punjab Agricultural University; 1975.

Saluja AK. Regulation and active site modification of ribulose biphosphate carboxylase/oxygenase. Ph.D. dissertation, Pullman; Washington State University; 1980.

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SELECTED ABSTRACTS:

1. Houlihan MJ, Powers RE, Saluja M, Saluja AK, Eigner SF, Steer ML. Accelerated pancreatic acinar cell regeneration in rats treated with caerulein. Federation Proceedings, 1985; 44:539.

2. Houlihan MJ, Saluja AK, Powers RE, Saluja M, Eigner SF, Steer ML. Effects of difluoromethylornithine (DFMO) upon pancreatic regeneration. Dig Dis Sci 1985; 30:975.

3. Saluja AK, Saluja M, Rutledge P, Leli U, Steer ML. Calcitonin gene-related peptide (CGRP) ameliorates caerulein-induced pancreatitis in rats. Dig Dis Sci 1987; 32:1186.

4. Powers RE, Saluja AK, Saluja M, Steer ML. Effect of a choline-deficient, 0.5% ethionine-containing (CDE) diet on mouse parotid salivary function. Pancreas, 1988; 3:614.

5. Saluja AK, Saluja M, Zavertnik A, Hirano T, Sengupta A, Steer ML. Failure of a potent gastrin antagonist, L-365-260 to protect against diet-induced pancreatitis in mice. Pancreas, 1989; 4:640.

6. Saluja A, Zavertnik A, Saluja M, Hirano T, Printz H, Steer ML. Failure of caerulein (CER) to stimulate amylase secretion from opossum pancreas. Pancreas, 1989; 4:640.

7. Saluja A, Saluja M, Zavertnik A, Hirano T, Lerch M, Ramarao P, Steer ML. A rise in cytoplasmic free calcium concentration ([Ca2+]i) is not necessarily coupled to amylase secretion in rat pancreatic acini. Gastroenterology, 1990; 98:A234

8. Saluja A, Zavertnik A, Ramarao P, Saluja M, Lerch MM, Hirano T, Dawra R, Steer M. Thapsigargin (TPG) and 2,5 di-butyl hydroquinone (BHQ)-two inhibitors of microsomal ATPase have different effects on intracellular calcium and secretion in pancreatic acini. Pancreas, 1990; 5: 728.

9. Ramarao P, Saluja A, Lerch MM, Saluja M, Hirano T, Dawra RK, Zavertnik A, Steer ML. Opossum pancreatic acini generate inositol trisphosphate (IP3) and secrete amylase in response to carbachol (CCh) stimulation but not in response to caerulein (CER) stimulation. Gastroenterology 1991; 100:A296.

10. Saluja A, Steer D, Lerch MM, Dawra R, Saluja M, Steer M. Failure of the cathepsin B inhibitor, E-64, to protect against caerulein and CDE-diet induced pancreatitis. Pancreas 1991; 6:718.

11. Nishino H, Saluja A, Maitre N, Runzi R, Dawra R, Saluja M, Steer ML. Somatostatin inhibits the in-vivo secretion of digestive enzymes stimulated by i.v. ethanol administration. Gastroenterology 1993; 104: A325.

12. Saluja A, Maitre N, Runzi M, Dawra R, Nishino H, Saluja M, Steer ML. Taxol alters the dose-dependence of secretagogue-induced pancreatitis and high dose inhibiton of digestive enzyme secretion from rat pancreas. Gastroenterology 1993;104: A333.

13. Runzi M, Saluja A, Dawra R, Saluja M, Nishino H, Steer ML. Inhibition of glycosylation leads to increased secretion of lysosomal enzymes from rat pancreatic acinar cells. Pancreas 1993; 8: 771.

14. Saluja A, Runzi M, Nishino H, Steer, ML. Failure of opossum pancreas to secrete amylase in response to caerulein. Pancreas 1993; 8:772.

15. Saluja A, Rutherford L, Nishino H, Runzi M, Saluja M, Cui ZJ, Grady T, Steer M. Depletion of pancreatic glutathione results in the inhibition of secretagogue-stimulated amylase secretion but does not prevent secretagogue-induced rise in intracellular calcium in rat acini. Gastroenterology 1994.

16. Lu L, Saluja A, Kaiser A, Yamanaka K, Yamaguchi Y, Donovan E, Steer M. Somatostatin blocks ethanol-induced release of cholecystokinin-releasing factor (CCK-RF) into the duodenum. Gastroenterology 1995;108:A372.

17. Adelson JW, Coutu JA, Saluja A, Steer M. Heterogeneity of the human exocrinepancreas: antidigestive enzyme antibody and lectin binding. Gastroenterology 1998; 114(4): A437.

18. Bhatia M, Saluja A, Lee HS, Frossard JL, Bhagat L, Steer, ML. Deletion of interleukin-1-beta converting enzyme does not prevent pancreatic acinar cell apoptosis induced by either a pancreatotoxin or by withdrawal of a trophic stimulation. Gastroenterology 1998; 114(4):A441.

19. Lee HS, Saluja A, Bhatia M, Bhagat L, Frossard JL, Wagner DD, Steer ML. The role of P- and E-selectins in caerulein induced pancreatitis. Pancreas 1998; 17:444.

20. Saluja A, Lee HS, Bhatia M, Frossard JL, Bhagat L, Steer ML. Pathogenesis of acute pancreatitis in mice: role of PAF and interstrain variation. Pancreas 1998;17:454.

21. Bhatia M, Saluja A, Lee HS, Frossard J-L, Bhagat L, Steer ML. CP-96,345, a substance P antagonist reduces the severity of caerulein-induced pancreatitis and pancreatitis-associated lung injury. Pancreas 1998;17:426.

22. Bhagat L, Saluja AK, Hiertaranta AJ, Akella U, Singh VP, Steer ML. Role of Tlymphocytes in regulating the severity of caerulein-induced pancreatitis and associated lung injury in mice. Gastroenterology 1999;116: A 1112.

23. Freedman SD, Urman SM, Bhagat L, Martinez Clark P, Steer ML, Saluja AK. Ethanol administration to CFTR (-/-) mice induces acute pancreatitis. Gastroenterology 1999;116: A 1124.

24. Bhagat L, Saluja AK, Hietaranta AJ, Singh VP, Akella U, Pan A, Steer, ML. Tlymphocytes are critical to the development of pancreatitis-associated but not endotoxin-induced injury. Pancreas 1999;19 (4):415.

25. Singh VP, Saluja AK, Bhagat L, Hietaranta AJ, Akella U, Pan A, Steer ML. Role of serine proteases in the regulation of exocytosis in the rat pancreatic acinar cell. Pancreas 1999:19 :439.

26. Bhagat L, Saluja AK, Akella U, Singh VP, Hietaranta AJ, Song, AM, Pan A, Steer, ML. Role of calcium in lysosomal enzyme redistribution and intra-acinar cell activation of trypsinogen in an in vitro model of pancreatitis. Gastroenterology 2000;118:A164.

27. Singh VP, Saluja AK, Bhagat L, Hietaranta A, Song A, Akella U, Pan A, Steer ML, Serine proteases regulate exocytosis and F-actin distribution in rat pancreatic acinar cells. Gastroenterology 2000; 118: G5316.

28. Bhagat L, Hietaranta AJ, Singh VP, Song AM, Mykoniatis A, van Acker GJD, Pan, A, Steer ML, Saluja AK, Water immersion stress prevents trypsinogen activation in the caerulein model of pancreatitis by altering intracellular calcium. Pancreas 2000; 21:432.

29. Singh VP, Bhagat L, Hietaranta AJ, Song AM, Pan A, van Acker GJD, Mykoniatis A, Steer ML, Saluja AK, NF-κB independent upregulation of Mob-1 mRNA expression in rat pancreas following supramaximal stimulation with caerulein. Pancreas 2000; 21:480.

30. Singh VP, Saluja AK, Bhagat L, Hietaranta AJ, Song AM, Pan A, van Acker GJD, Mykoniatis A, Steer ML, Serine protease inhibition causes apical F-actin redistribution and inhibition of Ca2+-mediated secretion in rat pancreatic acinar cells Pancreas 2000; 21:480.

31. Song A, Bhagat L, Hietaranta AJ, Singh VP, Mykoniatis A, van Acker GJD, Pan A, Saluja AK, Steer ML, Macrophage migration inhibitory factor (MIF) does not have a significant effect on the severity of caerulein-induced pancreatitis and associated lung injury in mice Pancreas 2000; 21:482.

32. van Acker GJD, Saluja AK, Bhagat L, Hietaranta AJ, Singh VP, Song AM, Mykoniatis A, Pan A, Steer ML. Relationship between intrapancreatic activation of trypsinogen and intrapancreatic sequestration of neutrophils following supramaximal stimulation with caerulein in mice. Pancreas 2000; 21:486.

33. Singh VP, Saluja AK, Bhagat L, Song A, Mykoniatis A, van Acker GJD, Steer ML, Secretagogue (caerulein)-induced intrapancreatic activation of trypsinogen is mediated by protein kinase C (PKC), Phosphoinositide-3-kinases (PI-3-Ks) and tyrosine kinases (TKs). (Gastroenterology 2001; 120(5) supplement 1. 1735)

34. Singh VP, Saluja AK, Bhagat L, Song A, Mykoniatis A, van Acker GJD, Steer ML Regulation of CXC-ELR chemokine expression in mouse acini after supramaximal stimulation with caerulein (Gastroenterology 2001; 120, No. 5 supplement 1. 704.

35. Bhagat L, Saluja AK, Hietaranta AJ, Akella U, Singh VP, Steer ML, Role of Tlymphocytes in regulating the severity of caerulein-induced pancreatitis and associated lung injury in mice (Gastroenterology 1999; 116(Gastroenterology 2001; 120(5) supplement 1. 2732

36. van Acker GJD, Saluja AK, Bhagat L, Singh VP, Song AM, Mykoniatis A and Steer ML, In vivo effects of cathepsin B inhibition on secretagogue-induced intrapancreatic activation of trypsinogen in mice. (Gastroenterology 2001; 120, No. 5 supplement 1. 704)

37. Bhagat L, Saluja AK, Singh VP, Song AM, van Acker GJD, Mykoniatis A and Steer ML, Role of actin cytoskeleton in caerulein-induced intra-acinar cell activation of trypsinogen in an in vitro model of pancreatitis. (Gastroenterology 2001; 120(5) supplement 1. 1734)

38. Bhagat L, Saluja AK, van Acker GJD, Singh VP, Song AM, Mykoniatis A and Steer ML, Lysosomal hydrolase/digestive zymogen co-localization and intra-acinar cell activation of trypsinogen: Which is the horse and which is the cart? (Gastroenterology 2001; 120(5) supplement 1. 2748)

39. van Acker GJD, Saluja AK, Singh VP, Bhagat L, Song AM, Mykoniatis A and Steer ML, Intrapancreatic activation of trypsinogen precedes and is required for neutrophil sequestration in the pancreas during secretagogue-induced pancreatitis in mice, (Gastroenterology 2001; 120(5) supplement 1. 2742)

40. Song AM, Bhagat L, Singh VP, Mykoniatis A, van Acker GJD, Saluja AK and Steer ML, Inhibition of cyclooxygenase-2 (COX-2) enzyme ameliorates the severity of caerulein-induced pancreatitis and associated lung injury in mice, (Gastroenterology 2001; 120(5) supplement 1. 2732).

41. van Acker GJD, Saluja AK, Bhagat L, Singh VP, Song AM, Steer ML. Intrapancreatic trypsinogen activation and acinar cell necrosis in secretagogue- and duct infusioninduced pancreatitis are leukocyte independent events. (Pancreas 2001).

42. Song AM, Saluja AK, Bhagat L, Singh VP, van Acker GJD, and Steer ML. Inhibition of 5-lipooxygenase ameliorates the severity of caerulein-induced pancreatitis and associated lung injury in mice. (Pancreas 2001).

43. Bhagat L, Singh VP, van Acker GJD, Song AM, Steer ML and Saluja AK. Arsenite, a non-thermal stressor, induces hsp70 expression in the pancreas and protects against secretagogue-induced pancreatitis by preventing trypsinogen and NF-κB activation. (Pancreas 2001).

44. Bhagat L, Saluja AK, Manzoor R, Steer ML. Role of Microtubules in Caerulein-induced intra-acinar cell activation of trypsinogen in an in vitro model of pancreatitis. Pancreas 2002.

45. Bhagat L, Song Am, Manzoor R, Singh VP, Steer ML, Saluja AK. Inhibition of poly (ADP-Ribose) polymerase attenuates the severity of caerulein-induced pancreatitis and associated lung injury in mice. Pancreas 2002.

46. Bhagat L, van Acker GJD, Manzoor R, Singh VP, Song AM, Steer ML, Saluja AK. Targeted deletion of heat shock factor (HSF-1) exacerbates the severity of secretagogue-induced pancreatitis. Pancreas 2002.

47. Bhagat L, Singh V, Charania M, Saluja A, Steer M. Role of Actin Cytoskeleton in caerulein-induced intra-acinar cell NF-_B activation in an In vitro model of pancreatitis. Gastroenterology 2002, Vol.122;A-282

48. Singh V, Saluja A, Bhagat L, Charania M, Navin S, Steer M. Proteinase activated receptors (PARS) regulate pancreatic acinar cell expression of the CXC-ELR chemokine KC. Gastroenterology 2002, Vol.122;A-285

49. Sharif R, Dawra R, Dhaulakhandi D, Ku YS, Kurt-Jones E, Finberg R and Saluja A. Deletion of CD-14 receptors ameliorates the severity of caerulein-induced pancreatitis. Pancreas 2003

50. Bhagat L, Dawra R, Dhaulakhandi D, Ku YS, Sharif R, Garg L and Saluja A. Overexpression of heat shock protein 70 protects against secretagogue-induced pancreatitis. Pancreas 2003.

51. Ku YS, Sharif R, Dhaulakhandi D, Dawra R, Bhagat L and Saluja A. Inhibition of poly (ADP-ribose) polymerase attenuates the severity of caerulein-induced pancreatitis and associated lung injury by inhibition of NFκ-B activation. Pancreas 2003

52. Singh V, Saluja A, Navina S, Bhagat L, Andrade-Gordon P, Steer M. Par-2 plays a protective role in pancreatitis. Gastroenterology 2003, Vol.124;A-94.

53. Pothoulakis C, Saluja M, Anton P, Pan A, Dawra R, Garg L, Blueher S, Mantzoros C, Saluja A. Leptin play san anti-inflammatory role in acute pancreatitis. Gastroenterology 2003, Vol.124;A-502.

54. R Sharif, R Dawra, D Dhaulakhandi, A Aghadassi, YS Ku, E Kurt-Jones, R Finberg and A Saluja. Role of toll-like receptors (tlr4) in caerulein induced pancreatitis. Pancreas 2004;29: 361

55. R. Dawra, A. Aghdassi, D. Dhaulakhandi, R. Sharif and A. Saluja. Glutathione depletion inhibits digestive enzyme secretion by preventing rearrangement of sub apical f-actin web in rat pancreatic acini. Pancreas 2004; 29:362.

56. D Dhaulakhandi, L Bhagat, R Dawra, R Sharif, A. Aghdassi, and A Saluja. Decreased neutrophil infiltration in the pancreas and lungs of hsp70 transgenic mice during caerulein-induced pancreatitis. Pancreas 2004; 29:361.

57. R Dawra, YS Ku, R Sharif , D Dhaulakhandi and A Saluja. Myeloperoxidase inhibitoryactivity in pancreas and lung- a simple method for its removal and extraction of myeloperoxidase. Pancreas 2004;29:362

58. R Sharif, R Dawra and A Saluja. Genetic deletion of Toll Like Receptor (tlr4) ameliorates arginine-induced pancreatitis in mice. Gastroenterology 2005; 128: 62.

59. R Dawra, R Sharif and A Saluja. Characterization of a new mouse model of acute pancreatitis induced by administration of arginine. Gastroenterology 2005; 128: 630.

60. V Singh, L Bhagat, R Dawra, R Sharif, S Navina and A Saluja. Protease Activated Receptor-2 (PAR-2) Protects Against Pancreatitis by Stimulating Digestive Enzyme Secretion. Pancreas 2005; 31:469.

61. R. Dawra, R. Sharif, P.A. Phillips, D. Dhaulakhandi, S. Ghaffoor and A. Saluja. Effect of 5-lipoxygenase inhibition on caerulein induced pancreatitis in cyclooxygenase-2 gene knockout mice. Pancreas 2005; 31:437.

62. R Sharif, R Dawra, PA Phillips, D Dhaulakhandi, and A Saluja. JNK Kinases Reduce the Severity of Arginine Induced Acute Pancreatitis. Pancreas 2005; 31:468.

63. A Aghdassi, PA Phillips, R Sharif, S Ghaffoor, R Dawra, MM Lerch, A Saluja.Depletion of Heat Shock Protein-70 (Hsp70) Causes Apoptosis in Pancreatic CancerCells. Pancreas 2005:31:431.

64. M Sahin-Toth, R Dawra, W Halangk, M Lerch and A Saluja. Trypsinogen isoforms inthe normal mouse pancreas. Pancreas 2005; 31:466.

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