Curriculum Vitae
Julia G. Davydova, M.D., Ph.D.

DEGREES:

M.D. (in Biochemistry)
1993, Siberian State Medical University, Tomsk City, Russia

Ph.D (in Pathophysiology)
1997, Siberian State Medical University and Research Institute of Pharmacology of the Tomsk Scientific Center of the Russian Academy of Medical Sciences, Tomsk City, Russia                                                      .                                        

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EDUCATION:

1987-1993
Graduate Training Program Siberian State Medical University. Tomsk, Russia.

1993-1996
Post Doctoral Training (Postgraduate Course) Pathophysiology Department of the Siberian State Medical University. Research Institute of Pharmacology of the Tomsk Scientific Center of the Russian Academy of Medical Sciences. Tomsk, Russia.

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ACADEMIC APPOINTMENTS:

11/06-Present
Research Associate /Assistant Professor
Department of Surgery
University of Minnesota, Minneapolis, MN

2003-11/2006
Research Associate
Division of Human Gene Therapy
University of Alabama at Birmingham. Birmingham, AL

2000-2003
Research Assistant
Division of Human Gene Therapy
University of Alabama at Birmingham. Birmingham, AL

1999-2000
Senior Lecturer
Biomedical Department, Tomsk State
Pedagogical University, Tomsk, Russia

1997-1999                                               
Lecturer
Biomedical Department
Tomsk State Pedagogical University, Tomsk, Russia

1996-1997                               
Research Associate
Central Research Laboratory
Siberian State Medical University, Tomsk, Russia

1993-1996
Postgraduate/Post Doctorial Fellow
Pathophysiology Department of the Siberian State Medical University
Research Institute of Pharmacology of the Tomsk Scientific Center of the Russian Academy of Medical Sciences, Tomsk, Russia

1992-1993
Research Assistant
Central Research Laboratory
Siberian State Medical University. Tomsk, Russia.

1990-1992
Research Technician
Central Research Laboratory
Siberian State Medical University. Tomsk, Russia.

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TEACHING EXPERIENCE: 

1997-2000
Lecturer/Senior lecturer of the Biomedical Disciplines.  Served as a Graduate thesis mentor. (Biomedical Department, Tomsk State Pedagogical University, Tomsk, Russia).

1995-1996
Course in the Pathophysiology for medical graduate students. M.D. thesis mentor. (Siberian Medical University. Tomsk, Russia).

1994-1997
Served as a Board Member of the Scientific Advisory Council of the Siberian State Medical University (Tomsk, Russia)

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VISITING LECTURES:

May 24, 2006
Invited Speaker: “Principles of Gene Therapy. Adenoviral Gene Therapy for Cancer”, Siberian State Medical University, Department of Biochemistry and Molecular Biology, Tomsk, Russia.

May 25 – 26, 2006
Short course of lectures for medical students “Advanced biomedical technologies and its clinical application”, Siberian State Medical University, Department of Biochemistry and Molecular Biology, Tomsk, Russia

June 21, 2006
Seminar: “Principles of Gene Therapy. Gene Therapy for Cancer”, Sayanogorsk State Hospital , Sayanogorsk, Russia.

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PROFESSIONAL SOCIETIES:

American Society of Gene Therapy

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MAJOR RESEARCH INTERESTS:

Gene therapy for cancer

Construction and improvement of Adenoviral therapeutic agents for gastrointestinal cancers

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BIBLIOGRAPHY (in reverse chronological order):

ARTICLES

1. Long P. Le, Helen N. Le, Igor P. Dmitriev, Julia G. Davydova, Tatyana Gavrikova, Seiji Yamamoto, David T. Curiel, Masato Yamamoto. Dynamic Monitoring of Oncolytic Adenovirus In Vivo by Genetic Capsid Labeling. Journal of the National Cancer Institute, February 1, 2006 Vol. 98, No. 3, 203-214.

2. M Yamamoto, N Nishimoto, J Davydova, T Kishimoto and D T Curiel. Suppressor of cytokine signaling-1 expression by infectivity-enhanced adenoviral vector inhibits IL-6-dependent proliferation of multiple myeloma cells. Cancer Gene Therapy. 2006 Feb;13(2):194-202.

3. Hidetaka A. Ono, Long P. Le, Julia G. Davydova, Tatyana Gavrikova and Masato Yamamoto. Noninvasive Visualization of Adenovirus Replication with a Fluorescent Reporter in the E3 Region. Cancer Research.  2005 Nov 15;65 (22):10154-8.

4. Tekant Y, Davydova J, Ramirez PJ, Curiel DT, Vickers SM, Yamamoto M. Oncolytic adenoviral therapy in gallbladder carcinoma. Surgery. 2005 May;137(5):527-35.

5. Ono HA, Davydova JG, Adachi Y, Takayama K, Barker SD, Reynolds PN, Krasnykh VN, Kunisaki C, Shimada H, Curiel DT, Yamamoto M. Promoter-controlled infectivity-enhanced conditionally replicative adenoviral vectors for the treatment of gastric cancer. J Gastroenterol. 2005 Jan;40(1):31-42.

6. Rivera AA, Davydova J, Schierer S, Wang M, Krasnykh V, Yamamoto M, Curiel DT, Nettelbeck DM. Combining high selectivity of replication with fiber chimerism for effective adenoviral oncolysis of CAR-negative melanoma cells. Gene Ther. 2004 Dec;11(23):1694-702.

7. Le LP, Everts M, Dmitriev IP, Davydova JG, Yamamoto M, Curiel DT. Fluorescently labeled adenovirus with pIX-EGFP for vector detection. Mol Imaging. 2004 Apr;3(2):105-16.

8. Davydova J, Le L.P.,Gavrikova T., Wang M., Krasnykh V., Yamamoto M. Infectivity-enhanced cyclooxygenase-2-based conditionally replicative adenoviruses for esophageal adenocarcinoma treatment. Cancer Research. 2004 Jul 15:64(12):4319-27.

9. Yamamoto M, Davydova J, Wang M, Siegal GP, Krasnykh V, Vickers SM, Curiel DT. Infectivity enhanced, cyclooxygenase-2 promoter-based conditionally replicative adenovirus for pancreatic cancer. Gastroenterology. 2003 Oct;125(4):1203-18.

10. Nettelbeck DM, Rivera AA, Davydova J, Dieckmann D, Yamamoto M, Curiel DT. Cyclooxygenase-2 promoter for tumour-specific targeting of adenoviral vectors to melanoma. Melanoma Res. 2003 Jun;13(3):287-92.

11. Nagi P, Vickers SM, Davydova J, Adachi Y, Takayama K, Barker S, Krasnykh V, Curiel DT, Yamamoto M. Development of a therapeutic adenoviral vector for cholangiocarcinoma combining tumor-restricted gene expression and infectivity enhancement. J Gastrointest Surg. 2003 Mar-Apr;7(3):364-71.

12. Yamamoto M, Davydova J, Takayama K, Alemany R, Curiel DT. Transcription initiation activity of adenovirus left-end sequence in adenovirus vectors with e1 deleted. J Virol. 2003 Jan;77(2):1633-7.

13. Ugdyzhekova DS, Davydova YG, Maimeskulova LA, Mechoulam R. Involvement of central and peripheral cannabinoid receptors in the regulation of heart resistance to arrhythmogenic effects of epinephrine. Bull Exp Biol Med. 2000 Nov;130(11):1087-9.

14. Ugdyzhecova DS, Maymeskulova LA, Davydova YG. Cannabinoid HU-210 increases cardiac tolerance to arrythmogenic effect of adrenaline and accinitine. Vestnik Arrythm. St.-Peterburg. 2000: V.19.p. 68-71.

15. Davydova YG. Hemoglobinsynthetic function of erythron at intravasal laser therapy of women with acute inflammations of genitals. Actual Problems of Pharmacology and Search of New Drugs. 1995. V.8: p.101.

16. Davydova YG, Makhmutkhodzhaev A. The functional characteristic of erythrocytes and neutrophiles in women with acute inflammation of uterus and Fallopian tubes. Ecogen. 1995. № 5: p.39.

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IN SUBMISSION

1. Ramírez PJ, Ono HO, Davydova J, Krasnykh V, Takayama K, Timme TL, Curiel DT, Yamamoto M and Vickers SM. Optimization of Vector for Pancreatic Cancer Adenoviral Gene Therapy (Pancreas)

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TEXTBOOKS

1. Nizkodubova S.V. Davydova J.G. Kulikova N.V. Healthy life stile. Textbook for students. Tomsk. 2000: 68p. (in Russian)

2. Kulikova N.V, Bernatskaya N.A, Bernatskii EO, Davydova J.G. Extreme conditions. Safety and defense. Textbook for students. Tomsk. 2000:138p. (in Russian)

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ABSTRACTS/PRESENTATIONS

1. Julia Davydova, Amy R. Nelson, Tatyana Gavrikova, Long P. Le, Hidetaka A. Ono, David T. Curiel, Masato Yamamoto. Monitoring of Promoter-controlled Adenoviral Replication with Noninvasive Imaging in Lung Cancer. American Society of Gene Therapy 9th Annual Meeting. Baltimore, MD, May 31 – June 4, 2006.

2. Julia Davydova, Hidetaka A. Ono, Long P. Le, Masato Yamamoto. Non-invasive in vivo Monitoring of Adenovirus Replication and its Application for Tumor Detection. The Japan Society of Gene Therapy, 12th Annual meeting, Tokyo, August 21-26, 2006.

3. Julia Davydova, Hidetaka A. Ono, Long P. Le, Masato Yamamoto. Non-invasive in vivo Visualization of Adenovirus Replication and its Application for Monitoring and Tumor Detection.  Cold Spring Harbor Meeting: “Target Definition & Vector design for Molecular Medicine”. New York, November 10-13, 2005. (oral)

4. Julia Davydova, Hidetaka A. Ono, Long P. Le, Tatyana Gavrikova, Seiji Yamamoto, Amy R. Nelson, David T Curiel, Masato Yamamoto. Noninvasive Optical Monitoring of Conditionally Replivative Adenovirus Replication. American Society of Gene Therapy 8th Annual Meeting. St. Louis, MO, June 1-5, 2005.

5. Hidetaka A. Ono, Long P. Le, Julia G. Davydova, Tatyana Gavrikova, Pedro J. Ramirez, David T. Curiel, and Masato Yamamoto. Non-invasive in vivo Visualization of Adenovirus Replication with Fluorescent Protein Gene Placed in E3 Region.  American Association of Cancer Research, April 16-20, 2005, Anaheim, CA. (oral)

6. Pedro J. Ramirez, Julia Davydova, Selwyn M. Vickers, David T. Curiel, Masato Yamamoto. Intravenous Administration of Infectivity Enhanced Conditionally Replicative Adenovirus Shows Augmented Antitumor Effect in Orthotopic Pancreatic Cancer Model. Digestive Disease Week, Chicago, May, 2005. (oral)

7. Tatyana Gavrikova, Julia Davydova, Long P. Le, Hidetaka A. Ono, Pedro J. Ramirez, Victor Krasnykh, David T. Curiel, Masato Yamamoto. New Generation Conditionally Replicative Adenovirus for Hormone-Refractory Prostate Cancer. American Society of Gene Therapy 7th Annual Meeting. Minneapolis, MN, June 2-6, 2004.

8. Hidetaka A. Ono, Long P. Le, Julia G. Davydova, Tatyana Gavrikova, Pedro J. Ramirez, Hiroshi Shimada, David T. Curiel, Masato Yamamoto. Imaging of Adenoviral Replication with a Fluorescent Reporter in the E3 Region. American Society of Gene Therapy 7th Annual Meeting. Minneapolis, MN, June 2-6, 2004.

9. Long P. Le, Igor P. Dmitriev, Julia G. Davydova, Masato Yamamoto, David T. Curiel. Genetic Labeling of Adenovirus with Luciferase on pIX for Vector Detection. American Society of Gene Therapy 7th Annual Meeting. Minneapolis, MN, June 2-6, 2004.

10. Long P. Le, Igor P. Dmitriev, Julia G. Davydova, Masato Yamamoto, David T. Curiel Genetic Labeling of Adenovirus with Red Fluorescent Proteins on pIX for Vector Detection. American Society of Gene Therapy 7th Annual Meeting. Minneapolis, MN, June 2-6, 2004.

11. Julia Davydova, Long P. Le, Tatyana Gavrikova, Hidetaka Ono, Pedro J. Ramirez, Victor Krasnykh, Minghui Wang, David T. Curiel, Masato Yamamoto. New Generation Conditionally Replicative Adenovirus for Esophageal Adenocarcinoma. Digestive Disease Week and the 104th Annual Meeting of the American Gastroenterological Association. New Orleans, LA, May 15-10, 2004 (oral).

12. Hidetaka A. Ono, Julia G. Davydova, Long P. Le, Pedro J. Ramirez, Tatyana Gavrikova, Victor N. Krasnykh, Chikara Kunisaki, Hiroshi Shimada, David T. Curiel, Masato Yamamoto. Optimization of Infectivity Enhanced Conditionally Replicative Adenoviral Vectors for the Gene Therapy of Gastric Cancer. Digestive Disease Week and the 104th Annual Meeting of the American Gastroenterological Association. New Orleans, LA, May 15-10, 2004.

13. Tekant Y, Ramirez PJ, Ono H, Krasnykh V, Davydova J, Gavrikova T, Long L, Curiel DT, Vickers SM, Yamamoto M. Optimazing Infectivity Enhanced, Conditionally Replicative Adenovirus for Gallbladder Cancer Gene Therapy. Digestive Disease Week and the 104th Annual Meeting of the American Gastroenterological Association. New Orleans, LA, May 15-10, 2004.

14. Ramirez PJ, Ono HA, Davydova J, Curiel DT, Vickers SM, Yamamoto M. Optimization of conditionally replicative adenovirus for cholangiocarcinoma. Digestive Disease Week and the 104th Annual Meeting of the American Gastroenterological Association. New Orleans, LA, May 15-10, 2004.

15. Ramirez PJ, Ono HA, Davydova J, Curiel DT, Vickers SM, Yamamoto M. Systemic administration of conditionally replicative adenoviruses in an orthotopic nude mouse pancreatic cancer model. Alabama chapter of American College of Surgeons, Point Clear, AL, June 12, 2004 (oral).

16. Dirk M. Nettelbeck, Angel A. Rivera, N. Sanjib Banerjee, Andrea L. Volk, Julia Davydova, Masato Yamamoto, Victor Krasnykh, Ramon Alemany, Thomas R. Broker, Louise T. Chow, Alexander Steinkasserer, and David T. Curiel. Engineering of Oncolytic Adenoviruses for Targeted and Efficient Virotherapy of Malignant Melanoma. European Society of Gene Therapy. Edinburgh, UK, November 14-17, 2003.

17. J. Davydova, L. Le, T. Gavrikova, H. Ono, P. Ramirez, M. Wang, V. Krasnykh, D. Curiel and M. Yamamoto. Transcriptionally and Transductionally Targeted Conditionally Replicating Adenovirus for Esophageal Adenocarcinoma. American Society of Gene Therapy 6th Annual Meeting. Washington, DC, June 4 –8, 2003.

18. D.L. Della, M. Yamamoto, V. Krasnykh, K.R. Zinn, J. Davydova, S. Chiz, D.J. Bushbaum. New Adenoviral Vectors for Molecular Chemotherapy of Prostate Cancer. American Society of Gene Therapy 6th Annual Meeting. Washington, DC, June 4 –8, 2003. (Oral)

19. D.M. Nettelbeck, A.A. Rivera, A.L. Volk, C. Balague, J. Davydova, V. Krasnykh, R. Alemany, D.T. Curiel. Engineering of Oncolytic Adenoviruses for Targeted and Efficient Virotherapy of Malignant Melanoma. American Society of Gene Therapy 6th Annual Meeting. Washington, DC, June 4 –8, 2003.

20.  P.J. Ramirez, H.A. Ono, J. Davydova, K. Takayama, H. Haisma, L.P. Le, T. Gavrikova, S.M. Vickers, D.T. Curiel, M. Yamamoto. Optimization of Tumor Specific Promoters for Pancreatic Cancer. American Society of Gene Therapy 6th Annual Meeting. Washington, DC, June 4 –8, 2003.

21. H.A. Ono, J. Davydova, L. Le, P.J. Ramirez, T. Gavrikova, H.J. Haisma, V. Krasnykh, H. Shimada, D.T. Curiel, M. Yamamoto. Transcriptional and Transductional Optimization od Adenoviral Vectors for Gastric Cancer. American Society of Gene Therapy 6th Annual Meeting. Washington, DC, June 4 –8, 2003.

22. L.P. Le, D.A. Matthews, J.G. Davydova, M.Yamamoto, D.T. Curiel. Core-Labeled Fluorescent Adenovirus for Viral Detection. American Society of Gene Therapy 6th Annual Meeting. Washington, DC, June 4 –8, 2003. (Oral)

23. L.P. Le, I. Dmitriev, J.G. Davydova, M. Yamamoto, and D.T. Curiel.  Fluorescently labeled adenovirus with IX-EGFP for vector detection. Society of Molecular Imaging 2nd Annual Meeting.  San Francisco, CA (2003).

24. L.P. Le, I. Dmitriev, J.G. Davydova, M. Yamamoto, and D.T. Curiel.  Fluorescently labeled adenovirus with IX-EGFP for monitoring conditionally replicative adenovirus replication and distribution. American Association of Cancer Research.  Washington, D.C. (2003).

25. Davydova J, Gavrikova T, Curiel DT, Yamamoto M. Transcriptionally and transductionally targeted conditionally replicating adenovirus for gastrointestinal cancers. The Japan Society of Gene Therapy 9th Annual meeting. Tokyo, Japan, July 18-20, 2003. (Oral)

26. J. Davydova, L. Le, T. Gavrikova, Hidetaka A. Ono, Pedro J. Ramirez, V. Krasnykh, J. Short, Minghui Wang, D.T. Curiel, M. Yamamoto. Transcriptionally and Transductionally Targeted Conditionally Replicating Agents for Esophageal Adenocarcinoma. Cold Spring Harbor Meeting: “Vector Targeting Strategies for Gene Therapy”. New York, March 20-23, 2003, (oral).

27. L.P. Le, I. Dmitriev, J.G. Davydova, M. Yamamoto, and D.T. Curiel.  Fluorescently labeled adenovirus with IX-EGFP for virus detection. Cold Spring Harbor Meeting: “Vector Targeting Strategies for Gene Therapy”. New York, March 20-23, 2003.

28. J. Davydova, L. Le, T. Gavrikova, H. Ono, P. Ramirez, M. Wang, V. Krasnykh, D.T. Curiel, M. Yamamoto. Infectivity Enhanced Cox-2-based Conditionally Replicative Adenoviruses for Esophageal Adenocarcinoma. University of Alabama at Birmingham Comprehensive Cancer center Annual research Retreat. Birmingham, AL, October, 2003.

29. H.A. Ono, J. Davydova, Y. Adachi, K. Takayama, H.J. Haisma, S.D. Barker, P.N. Reynolds, V.N. Krasnykh, D.T. Curiel, M. Yamamoto. Transcriptional Optimization of Infectivity Enhanced Conditionally Replicative Adenoviral vectors for the Treatment of Gastric Cancer. University of Alabama at Birmingham Comprehensive Cancer center Annual research Retreat. Birmingham, AL, October, 2003.

30. P.J. Ramirez, H.A. Ono, J. Davydova, H.J. Haisma, V. Krasnykh, K. Takayama, T.L. Timme, D.T. Curiel, M. Yamamoto, S.M. Vickers. Optimization of Conditionally Replicative Adenoviruses for Pancreatic Cancer. University of Alabama at Birmingham Comprehensive Cancer center Annual research Retreat. Birmingham, AL, October, 2003.

31. L.P. Le, I.P. Dmitriev, J.G. Davydova, M.Yamamoto, D.T. Curiel. Fluorescently Labeled Adenovirus with IX-EGFP for Vector Detection. University of Alabama at Birmingham Comprehensive Cancer center Annual research Retreat. Birmingham, AL, October, 2003.

32. M. Yamamoto, J. Davydova, L.P. Le, P.J. Ramirez, T. Gavrikova, V. Krasnykh, D. Curiel. Infectivity Enhanced COX-2 Promoter-Based Conditionally Replicative Adenovirus for Esophageal Adenocarcinoma. Digestive Disease Week and the 104th Annual Meeting of the American Gastroenterological Association. Orlando, FL, May 17-22, 2003.

33. J. Davydova, L. Le, P. Nagi, K. Suzuki, V. Krasnykh, D.T. Curiel, M. Yamamoto. Cox-2 Promoter-Driven and Infectivity-Enhanced Adenoviral Vectors are Promising Therapeutic Agents for Esophageal Adenocarcinoma. American Society of Gene Therapy 5th Annual Meeting. Boston, MA, June 4 –9, 2002.

34. P. Nagi, J. Davydova, S. Barker, Y. Adachi, K. Takayama, V. Krasnykh, S.M. Vickers, D.T. Curiel, M. Yamamoto. Development of a therapeutic adenoviral vector for cholangiocarcinoma combining infectivity enhancement and tumor-restricted gene expression. American Society of Gene Therapy 5th Annual Meeting. Boston, MA, June 4 –9, 2002.

35. M. Yamamoto, J. Davydova, K. Suzuki, P. Nagi, L. Le, V. Krasnykh, S.M. Vickers, D.T. Curiel. Cyclooxygenase-2 (COX-2) promoter-based infectivity enhanced conditionally replicative adenovirus for COX-2 positive gastrointestinal cancer. American Society of Gene Therapy 5th Annual Meeting. Boston, MA, June 4 –9, 2002. (Oral)

36. Le LP, D.A. Mattews, J. Davydova, M. Yamamoto, D.T. Curiel. Development of Internally Labeled Adenovirus with EGFP for Imaging. American Society of Gene Therapy 5th Annual Meeting. Boston, MA, June 4 –9, 2002.

37. M. Yamamoto, J. Davydova, P. Nagi, K. Suzuki, S.M. Vickers, D.T. Curiel. Cyclooxygenase-2 (Cox-2) Promoter-Based Conditionally Replicative Adenovirus for Cox-2 Positive Gastrointestinal Cancers. Digestive Disease Week and the 103rd Annual Meeting of the American Gastroenterological Association. San Francisco, CA, May 19-22, 2002.

38.  P. Nagi, J. Davydova, S. Barker, Y. Adachi, K. Takayama, V. Krasnykh, S.M. Vickers, D.T. Curiel, M. Yamamoto. Development of a therapeutic adenoviral vector for cholangiocarcinoma combining infectivity enhancement and tumor-restricted gene expression. Digestive Disease Week and the 103rd Annual Meeting of the American Gastroenterological Association. San Francisco, CA, May 19-22, 2002.

39. Y.G. Davydova.  Blood and Bone Marrow Indices in Chronic Experiment with Ultradispersive Powders of LiPF6. Conference Dedicated to 150 anniversary of I.P. Pavlov. Tomsk, Russia, 1999. 

40. Y.G. Davydova. Bone-Marrow Indices of Rats in Chronic Experiment with Ultradispersive Powders of PF5. The Forum of Young Scientists. Tomsk, Russia, 1999.

41. S.V. Nizkodubova, Y.G. Davydova, A.N. Baikov, M.G. Belousova. Hematological indices of rats in chronic experiment with ultradispersive powders of LiPF6. Conference “Biomedical Aspects of Neuro-Humoral Regulation”. Tomsk, Russia, 1997.

42. Y.G. Davydova. Hemoglobinsynthetic function of erythron in women with acute inflammations of genitals. Proceeding of Postgraduate students of the Siberian State Medical University. Tomsk, Russia, 1995.

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