Curriculum Vitae
Raja Kandaswamy, M.D.

Education
Postdoctoral Training
Academic Appointments
Clinical Appointments
Reviewer
Grant Support
   Completed, Active, Pending
Certification and Licensure
Licensing Exams
Awards
Memberships
Teaching Activities
Courses
Bibliography*
   Publications, Peer Reviewed
   Publications, Non Peer Reviewed
   Book Chapters
   Oral Presentations
   Poster Discussions
   Poster Presentations
   Invited Lectures
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EDUCATION

May 1981, Anglo Indian School Leaving Certificate
   St. Bede's Anglo Indian High School, Madras, India
   Passed with "Distinction Honors"

May 1983, Higher Secondary School Leaving Certificate
    St. Bede's Anglo Indian Higher Secondary School, Madras, India
    Passed with "Distinction Honors"

Oct 1983 - May 1988, MBBS Degree
    Kilpauk Medical College, University of Madras, India
   Aggregate Scores in "First Class"

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POSTDOCTORAL TRAINING

Jun 1988 - Jun 1989, Rotating Internship
    Kilpauk Medical College & Hospitals
    University of Madras, Madras, India  

Jul 1990 - Jun 1991, Residency in Psychiatry
    University of Toronto
    Toronto, Ontario, Canada

Jul 1991 - Jun 1992, Residency in Transitional Medicine
    Howard University Hospital, Washington, D.C.

Jun 1992 - Jun 1997,  Residency in General Surgery
    Howard University Hospital, Washington, D.C.             

Jul 1997 - Jan 1999, Fellowship in Multi Organ Transplant Surgery
    University of Minnesota, Minneapolis, MN

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ACADEMIC APPOINTMENTS

Jun 1989 - Oct 1989, Medical Officer in Surgery
    Pallava Hospital, Madras, India

Jan 1990 - Jun 1990, Medical Observer
    Dept. of Psychiatry, 6
    Toronto Western Hospital, Ontario, Canada

May 1998 - Jun 1999, Instructor in Surgery
    University of Minnesota, Dept. of Surgery, Transplant Division, Minneapolis

Jul 1999 - June 2006, Assistant Professor of Surgery
    University of Minnesota, Dept. of Surgery, Transplant Division, Minneapolis

Jul 2006 - Present, Associate Professor of Surgery
    University of Minnesota, Dept. of Surgery, Transplant Division, Minneapolis

2003 - Present, Director of Organ Procurement and Preservation
    Diabetes Institute of Immunology and Transplantation
    Department of Surgery, University of Minnesota

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CLINICAL APPOINTMENTS

July 1999-present, Staff Physician
University of Minnesota Medical Center, Fairview, Minneapolis

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REVIEWER

American Journal of Kidney Diseases
Clinical Transplantation
Transplantation
Grant Reviewer, National Kidney Foundation, 2003

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GRANT SUPPORT

Completed

Agency:  Novartis
Project:  A Multicenter, Randomized, Partially-Blinded Study of the Safety and Efficacy of FTY-720 Reduced-Dose Neoral in de novo Adult Renal Transplant Recipients
Role:  Principal Investigator

Agency: Roche Pharmaceuticals
Project: Prospective, Open-label, Randomized Comparative Trial of Mycophenolate Mofetil Versus Sirolimus, with Steroid withdrawal, using a Tacrolimus Based Immunosuppressive Protocol in Pancreas After Kidney Transplantation
Role: Principal Investigator
Funding period: 9/14/00-7/31/02

Agency:  Novartis Pharmaceuticals
Project:  Islet Transplantation in Diabetic Nonhuman Primates Treated with Basilixmab, TP-20, FTY720, RAD001 and Cyclosporine
Role:  Coinvestigator

Agency: NIH/NIAID/Immune Tolerance Network C99B901251
Project: A multi-center trial of solitary islet transplantation in Type I Diabetes
Role: Co-Investigator
Funding Period:  10/1/1999-9/30/2002

Agency: Wyeth-Ayerst Pharmaceuticals
Project:  A Prospective, Open-Label, Randomized Trial of Steroid Avoidance, Using a Sirolimus and Tacrolimus Based Immunosuppressive Protocol in Simultaneous Pancreas-Kidney Patients.
Principal Investigator:  Raja Kandaswamy, MD (1% effort)
Funding Period: 10/23/2000-8/31/2003

Agency: JDRF
Project: JDF Islet Transplant Center Core
Role: Coinvestigator
Funding Period: 9/1/02-8/31/03
Percent Effort: 1

Agency: Immerge BioTherapeutics
Project: Xenogenic Porcine Islets
Role: Coinvestigator (effort 5%)
Funding Period: 11/1/02-6/30/03

Agency: Immerge BioTherapeutics, Inc.
Project:  Porcine Islet Transplantation in Diabetic Non-Human Primates Treated with Basiliximab, TP-10, FTY-720, RAD001
Role: Co-Investigator
Funding period: 11/1/2001-6/30/2003

Agency: Roche Pharmaceuticals – RO49272
Project: Single Donor, Islet Allotransplantation in Patients with Type I Diabetes
Role: Co-Investigator
Funding period:  9/21/2000-4/30/2004

Agency:  JDRF/UCSF 4-1999-841
Project:  hOKT3y1 (Ala-Ala) Combined with Sirolimus and Delayed Tacrolimus in Surgical and Type 1 Diabetic Islet Allograft Recipients (part of Dr. Hering’s JDRF Islet Transplantation Center of University of California at San Francisco and the University of Minnesota)
Role:  Co-Investigator
Funding period:  9/1/2000-8/31/2004

Agency: NIH/NCRR U42RR16598-01
Project: Human pancreatic islet cell resources
Principal Investigator: Raja Kandaswamy, MD and Bernhard Hering, MD
Role: Co-Principal Investigator (effort 2%)
Funding period:  9/1/2001-8/31/2006

Agency:  NIH
Project: Gene Polymorphisms and Kidney Transplant Outcome
Principal Investigator: William Oetting, Ph.D.
Role:  Co-Investigator (effort 5%)
Funding period:  8/1/2002-7/31/2006

Agency: Dompé
Project: A Phase 2, multi-center, randomized, double-blind, placebo-controlled, parallel-group (3 arms) pilot study to assess the efficacy, the safety and the pharmacokinetics of two treatment schedules of reparixin in the prevention of delayed graft function after kidney transplantation in high risk patients
Role: Co-investigator (effort 1%)
Funding period: 9/1/2005-8/30/2006

Agency: UCSF/JDRF
Project: Basiliximab and oral FTY720 and RAD 001 in Islet Transplantation
Role: Coinvestigator (effort 5%)
Funding Period: 2/1/04-1/31/07

Active

Agency: NIH/NCRR U42RR16598-01
Project: Human pancreatic islet cell resources
Principal Investigator: Raja Kandaswamy, MD and Bernhard Hering, MD
Role: Co-Principal Investigator
Funding period:  9/1/2001-7/31/2009
Percent effort: 2
Dr. Kandaswamy is a Co-Investigator on this project. The University of Minnesota Pancreatic Islet Cell Resource Center will be responsible for the procurement of pancreata, isolation and quality control of islet cell preparations, and distribution of islets for approved research or clinical protocols. The center will also perform research and development to improve islet isolation techniques, determine the physiologic and genomic components that are correlated with longevity, function, and portability of pancreatic islets.

Agency: Juvenile Diabetes Research Foundation
Project: The Islet Sanctuary Project 2: Engraftment and Function of Islet Allografts Transplanted to the Engineered SIS
Award Number: 7-2005-1167
Principal Investigator: Raja Kandaswamy
Role: Principal Investigator
Funding Period: 09/01/2005-08/31/2008
Percent Effort: 5

Agency: NIAID
Project: Clinical Center – Outcome of Live Organ Donors
Award Number: 1U01-AI069550
Role: Co-investigator
Funding Period: 07/15/2006-06/30/2011
Percent Effort: 5

Agency: JDRF
Project: JDRF Pig to Non-Human Primate Islet Xenotransplantation - Transplantation in Non-Human Primates (Project 1)
Award Number: 21-2006-881
Role: Co-Investigator
Funding Period: 01/01/2007-12/31/2009
Percent Effort: 2
Dr. Kandaswamy is a co-investigator on this project.  In light of the promising results obtained after intraportal transplantation of porcine islets in nonhuman primates we will examine the efficacy of our base immunosuppressive protocol in combination with other immunotherapeutics tested for their ability to substitute for á–CD154.  If possible, the use of investigational drugs will be avoided.  This approach is expected to result in the development of a clinically applicable regimen for submission to the FDA. Contact Info: Pearl Fields 212-479-7603, pfields@jdrf.org

Agency: Wyeth Pharmaceuticals
Project: Calcineurin-sparing in a steroid-free maintenance immunosuppression protocol
Award Number: 0468H1-4419
Role: Co-Investigator
Funding Period: 6/26/07-9/30/11
Percent Effort: 1

Pending Support

Agency:  NIH
Project:  Advancing Islet Transplants for Type 1 Diabetes Care - Clinical Trial
Award Number: AI65193
Principal Investigator: Bernhard Hering, MD
Role:  Co-Investigator
Funding period:  9/1/2007-8/31/2010
Percent Effort: 2
Dr. Kandaswamy is a co-investigator on this project. The goal of the project is to develop islet transplants for patients with microvascular complications by improving the efficacy of islet transplants to reverse diabetes, minimize the risks of immunosuppressive therapy and demonstrate the regression of microvascular lesions in islet recipients.  Contact Info:  Nancy D. Bridges  nbridges@niaid.nih.gov  (301) 402-0846

Agency:  Roche
Project:  A Prospective Randomized Trial of Extended Alemtuzumab vs. Daclizumab Using a Steroid and Calcineurin Inhibitor (CNI) Free Maintenance Regimen in Pancreas Transplant Alone (PTA) Recipients
Principal Investigator: Raja Kandaswamy, MD
Role:  Principal Investigator

Agency:  DIIT
Project:  One-Year, Single-Center, Prospective, Open-Label Study of the Safety and Preliminary Efficacy of Simultaneous Living Donor Islet Kidney Transplantation in Type I Diabetic Recipients.
Principal Investigator:  Raja Kandaswamy, MD
Role:  Principal Investigator
Percent Effort: 10

Agency:  NIH-NIAID
Project:  Preemptive Tolerization in Preclinical Islet and Kidney Transplantation-Project 1
Award Number: n/a (PI: BJ Hering)
Principal Investigator: Bernhard Hering, MD
Role:  Co-Investigator
Funding period:  07/01/2007-06/30/2012
Percent Effort: 2
Dr. Kandaswamy is a co-investigator on this project. The long-term goal of this Project is to develop a clinically applicable tolerogenic protocol for application in islet allotransplantation. The central features of our basic protocol (Group A) are pretransplant apoptotic donor lymphocyte transfusion (ADLT), administration of antagonistic Ą-CD40 mAb, CTLA4Ig, and sirolimus, as well as transplantation of cultured, antigen-presenting cell (APC)-depleted islets to the bioengineered omental pouch.

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CERTIFICATION AND LICENSURE

Certification
American Board of Surgery, 1998

Licensure
Minnesota Medical License, 1997-current
DEA, 1997-current
District of Columbia Medical License, 1995-2000
Educational Medical License in Ontario, Canada, 1990-91
General Medical License, Tamil Nadu, India

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LICENSING EXAMS

US National Board of Medical Examiners - Part II - April 1990
ECFMG English Test - July 1990
FMGEMS - Day I - Jan 1991
FLEX (Michigan) - Jun1991
Canada  Medical Council of Canada Evaluating Exam - May 1990
Medical Council of Canada Qualifying Exam (LMCC) - May 1991

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AWARDS

1984-1985, Best cadet & Best Shot Awards
  National Cadet Corps, India

1991-1992, Nominated as "Intern of the Year"
  Transitional Medicine Program
  Howard University Hospital, Washington, D.C.

1992-2000, AMA Physician's Recognition Award

Aug 1996, Poster Exhibit Contest - Second place
  101st Annual Convention & Scientific Assembly
  National Medical Association, Chicago, IL   

Sep 7, 1996, Laparoscopic Skills Top Gun Shootout - Third place
  Conducted by Yale University School of Medicine
  ACS Congress, San Francisco, CA

May 1997, Hospital-wide Outstanding Resident Award
  Howard University Hospital Medical Staff Association

Jun 1997, Chairman's Award for Best Chief Resident
  Department of Surgery, Howard University Hospital

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MEMBERSHIPS

Ontario Medical Association, 1990-91
Canadian Psychiatric Association, 1990-91
American Medical Association, 1992-2000
American College of Surgeons, 1995-current
National Medical Association, 1996-97
Intl. Pancreas and Islet Transplant Association, 2002-current
Transplantation Society, 2003-current
American Society of Transplant Surgeons, 2007-current
Minnesota Medical Association, 2007-current

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TEACHING ACTIVITIES

Physician Assistant Preceptor Supervisor, Stephanie Kroon, 2001
Supervision of Transplant Fellows, 1999-present
Surgery Resident Teaching Conference, 1999-2003
Surgery Grand Rounds
Featured Faculty – Living Donor Transplantation, 1st National Course, Sponsored by King’s College, London, Supported by the British Transplant Society, March 2005.

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COURSES

May 1984, Rock Climbing course, National Cadet Corps
Oct 1985, Trekking Expedition, National Cadet Corps
Jan 1986, Comprehensive Cardiac Workshop
  Conducted by Cardiac Medicaid & Research Foundation
Jan 1989, "IBM Utilities" - Software Course
  Pragati Computers Training Division
Aug 1993, Advanced Trauma Life Support Course
Jul 1996, Advanced Cardiac Life Support Course
Sep 1996, ACLS Instructor Course
Jun 7, 1996, Communication Skills Workshop
  Conducted by Impact Communications, Inc.
  Renaissance Mayflower Hotel, Washington, D.C.
Jun 7-9, 1996, New Directions in the Management of Hospital Infections
  Renaissance Mayflower Hotel, Washington, D.C.
Jun 1998, Advances in hepatobiliary and pancreatic surgery, University of Minnesota (UMN)
Jun 1999, Advances in Breast, Endocrine and Cancer Surgery, UMN
Jun 7-9, 2000 Advances in Trauma & Critical Care Surgery, UMN
Jun 2001, Advances in Gastrointestinal Surgery, UMN
Jun 2002, Advances in Hepatic, Biliary, and Pancreatic Surgery, UMN
Jun 2003, Advances in Breast, Endocrine, and Cancer Surgery, UMN
Jun 2004, Advances in Trauma and Critical Care Surgery, UMN
Jun 2005, Advances in Gastroinestinal and GI Laparoscopic Surgery, UMN
2006, Advanced Laparoscopic Skills Course, University of Chicago

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