Curriculum Vitae
Agustin P. Dalmasso, M.D.

Academic Degrees
Board Certification
Professional Record
Research Interests
Recent Publications

ACADEMIC DEGREES:

M.D., University of Cordoba, Argentina, 1958
D.M.Sc., University of Cordoba, Argentina, 1963

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BOARD CERTIFICATION:

American Board of Pathology, 1972

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PROFESSIONAL RECORD:

Research Associate, Department of Physiology, University of Cordoba, Argentina, 1958-1960

Research Fellow, Department of Physiology and Pediatrics, University of Minnesota, 1960-1963

Research Fellow, Department of Experimental Pathology, Scripps Clinic and Research Foundation, La Jolla, California, 1963-1966

Head, Immunology Section, Department of Medicine, School of Medicine, University of Buenos Aires, and Career Investigator, National Research and Technology Council, Argentina, 1966-1970

Associate Professor of Laboratory Medicine and Pathology, University of Minnesota Medical School, and Chief of Immunology and Blood Bank, Veterans Administration Medical Center, Minneapolis, Minnesota, 1970-1974

Professor of Laboratory Medicine and Pathology, University of Minnesota Medical School, and Chief of Immunology and Blood Bank, Veterans Administration Medical Center, Minneapolis, Minnesota, 1974-1999

Professor of Surgery and Laboratory Medicine and Pathology, University of Minnesota Medical School, 1999-present

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RESEARCH INTERESTS:

Biology of complement
Endothelial cell immunobiology
Transplantation immunology

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RECENT PUBLICATIONS:

Black SM, Grehan JF, Rivard AL, Benson BA, Wahner AE, Koch AE, Levay-Young BK, Dalmasso AP. Porcine Endothelial Cells and Iliac Arteries Transduced with AdenoIL-4 Are Intrinsically Protected, through Akt Activation, against Immediate Injury Caused by Human Complement. J Immunol. 2006 Nov 15;177(10):7355-63.

Wust, S.K., Blumenthal, M.N., Benson, B.A., Corazalla, E.O. and Dalmasso, A.P.:  Complement in asthma: sensitivity to activation and generation of C3a and C5a via the different complement pathways.  Transl Res. 2006 Oct;148(4):157-63.

Grehan, J.F., Levay-Young, B.K., Benson, B.A., Abrahamsen, M.S and Dalmasso, A.P.:  αGal ligation of pig endothelial cells induces protection from complement and apoptosis independently of NF-κB and inflammatory changes. Am. J. Transplant. 2005, 5:712-719.

Grehan, J.F., Levay-Young, B.K., Fogelson, J.L., François-Bongarçon, V., Benson, B.A., and Dalmasso, A.P.:  IL-4 and IL-13 induce protection of porcine endothelial cells from killing by human complement and from apoptosis through activation of a phosphatidylinositide 3-kinase/Akt pathway. J. Immunol., 2005, 175:1903-1910.

Kirchhof, N., Shibata, S., Wijkstrom, M., Kulick, D.M., Salerno, C.T., Clemmings, S.M., Heremans Y., Galili, U., Sutherland, D.E.R., Dalmasso, A.P. and Hering, B.J.:   Reversal of diabetes in nonimmunosuppressed Rhesus macaques by intraportal porcine islet xenografts precedes acute cellular rejection.  Xenotransplantation, 2004, 11:396-407.

Salerno, C.T., Kulick, D.M., Yeh, C.G., Guzman Paz, M., Higgins, P.J., Benson, B.A., Park, S.J., Shumway, S.J., Bolman, R. M. and Dalmasso, A.P.: A soluble chimeric inhibitor of C3 and C5 convertases, CAB-2, prolongs graft survival in pig-to-rhesus monkey heart transplantation. Xenotransplantation, 2002 Mar;9(2):125-34.

Kulick, D.M., Salerno, C.T., Dalmasso, A.P., Park, S.J., Guzman Paz, M., Fodor, W.L. and Bolman, R.M.: Transgeneic swine lungs expressing human CD59 are protected from injury in a pig-to-human model of xenotransplantation. J. Thorac. Cardiovasc. Surg., 2000, 119:690-699. 

Dalmasso, A.P., Benson, B.A., Johnson, J.S., Lancto, C. and Abrahamsen, M.S.: Resistance against the membrane attack complex of complement induced in porcine endothelial cells with a gala(1-3)gal binding lectin: up-regulation of CD59. J. Immunol., 2000, 164:3764-3773.  

Kroshus, T.J., Salerno, C.T., Yeh, C.G., Higgins, P.J., Bolman, R.M. and Dalmasso, A.P.: A recombinant soluble chimeric complement inhibitor composed of human CD46 and CD55 reduces acute cardiac tissue injury in models of pig-to-primate heart transplantation. Transplantation, 2000, 69:2282-2289. 

Kerr, S.R., Dalmasso, A.P., Kirschfink, M. and Matas, A.J.: Mouse-to-rabbit xenotransplantation: a new animal model of hyperacute rejection mediated by the classical complement pathway. Transplantation, 1999, 67:360-365. 

Janoff, E.N., Fasching, C., Orenstein, J.M., Rubins, J.B., Opstad, N.L. and Dalmasso, A.P.: Killing of Streptococcus pneumoniae by capsular polysaccharide-specific polymeric IgA, complement and phagocytes. J. Clin. Invest., 1999, 104:1139-1147.

Kronson, J.W., Hering, B.J., Sutherland, D.E.R., Tanioka, Y., Leone, J.P., Kirchhof, N. and Dalmasso, A.P. Posttransplant nonfunction of canine islets in PVG rats deficient in complement component C6. Transplantation, 1998, 65:1549-1554.

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